Hydrothermal Deposition of PCN-224 on 3D-Printed Porous β-Ca2SiO4 Scaffolds for Bone Regeneration

被引：11

作者：

Du, Jianhang ^{[1
]}

Liu, Weiye ^{[2
]}

Kang, Zhanrong ^{[1
]}

Yu, Bin ^{[3
]}

Li, Dejian ^{[1
]}

Ding, Huifeng ^{[3
]}

Huang, Jianming ^{[1
]}

机构：

[1] Fudan Univ, Dept Orthopaed, Shanghai Pudong Hosp, Pudong Med Ctr, Shanghai 201399, Peoples R China

[2] Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, Shanghai 200093, Peoples R China

[3] Fudan Univ, Dept Orthopaed, Shanghai Publ Hlth Clin Ctr, Shanghai 200032, Peoples R China

来源：

ADVANCED ENGINEERING MATERIALS | 2022年 / 24卷 / 08期

关键词：

bone tissue engineering; hydrothermal method; metal-organic frameworks; PCN-224; beta-Ca2SiO4; 3D printing; CALCIUM-PHOSPHATE CERAMICS; BIOACTIVE GLASS; OSTEOGENIC ACTIVITY; CASIO3; CERAMICS; IN-VIVO; TITANIUM; CEMENT; DIFFERENTIATION; HYDROXYAPATITE;

D O I：

10.1002/adem.202101550

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

3D-printed bioceramics derived from silicone resin are of great interest in bone tissue engineering owing to their simple processes and low cost. Herein, PCN-224, as a subclass of metal-organic frameworks (MOFs), is successfully fabricated and deposited on the surface of 3D-printed porous beta-Ca2SiO4 (C2S) scaffolds. The composite scaffolds possess uniform interconnected macropores (approximate to 400 mu m), with increased porosity and slower degradation. The results indicate that deposition of PCN-224 significantly promotes cell proliferation and the expression of osteogenesis-related genes. Moreover, the composite scaffolds significantly improve calvarial defect healing in rats, compared with C2S scaffolds. Therefore, the PCN-224-modified 3D-printed porous C2S composite scaffolds are promising candidates for bone tissue engineering.

引用

页数：11

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