A TBET based BODIPY-rhodamine dyad for the ratiometric detection of trivalent metal ions and its application in live cell imaging

被引：41

作者：

Chereddy, Narendra Reddy ^{[1
]}

Raju, M. V. Niladri ^{[1
,3
]}

Reddy, B. Manohar ^{[1
]}

Krishnaswamy, Venkat Raghavan ^{[2
]}

Korrapati, Purna Sai ^{[2
]}

Reddy, B. Jagan Mohan ^{[3
]}

Rao, Vaidya Jayathirtha ^{[1
]}

机构：

[1] CSIR Indian Inst Chem Technol, Crop Protect Chem Div, Hyderabad 500007, Andhra Pradesh, India

[2] CSIR Cent Leather Res Inst, Biomat Div, Chennai 600020, Tamil Nadu, India

[3] Adikavi Nannaya Univ, Dept Organ Chem, Rajahmundry 533105, India

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2016年 / 237卷

关键词：

BODIPY-rhodamine dyad; Through bond energy transfer; Trivalent metal ions; Ratiometric sensors; Live cell imaging; IRON REGULATORY PROTEINS; CU2+ IONS; SELECTIVE DETECTION; PROBE; CHEMOSENSOR; ALUMINUM; CHROMIUM; SENSOR; RING; HG2+;

D O I：

10.1016/j.snb.2016.06.131

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel fluorescent BODIPY-rhodamine dyad probe that operates based on through bond energy transfer (TBET) phenomenon has been synthesized and its application in the detection of biologically relevant metal ions is explored. Among several metal ions, the probe selectively responds to the addition of trivalent metal ions (Al3+, Cr3+ and Fe3+) through its signature absorbance and fluorescence characteristics and permits their ratiometric detection. The trivalent metal ion detection ability of the probe is unaffected with the presence of other commonly coexistent ions. The probe is highly sensitive and it can detect the trivalent metal ions even at ppb level concentrations. The probe is nontoxic under the experimental conditions, cell permeable and useful for the imaging of Al3+, Cr3+ and Fe3+ ions present in W138 (normal lung fibroblast) cells. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：605 / 612

页数：8

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