Platelet Disorders in Children: A Diagnostic Approach

被引：50

作者：

Israels, Sara J. ^{[1
]}

Kahr, Walter H. A. ^{[2
]}

Blanchette, Victor S. ^{[2
]}

Luban, Naomi L. C. ^{[3
]}

Rivard, Georges E. ^{[4
]}

Rand, Margaret L. ^{[2
]}

机构：

[1] Univ Manitoba, Dept Pediat & Child Hlth, Winnipeg, MB R3E 0V9, Canada

[2] Hosp Sick Children, Div Haematol Oncol, Toronto, ON M5G 1X8, Canada

[3] George Washington Univ, Sch Med & Hlth Sci, Div Lab Med, Childrens Natl Med Ctr,Dept Pediat & Pathol, Washington, DC 20052 USA

[4] Ctr Hosp Univ St Justine, Montreal, PQ, Canada

来源：

PEDIATRIC BLOOD & CANCER | 2011年 / 56卷 / 06期

关键词：

child; platelet disorders; platelet function tests; review; thrombocytopenia; VON-WILLEBRAND-DISEASE; LIGHT TRANSMISSION AGGREGOMETRY; UROKINASE PLASMINOGEN-ACTIVATOR; FACTOR-V QUEBEC; INHERITED THROMBOCYTOPENIAS; BLEEDING SYMPTOMS; ELECTRON-MICROSCOPY; AGGREGATION; EXPRESSION; MANAGEMENT;

D O I：

10.1002/pbc.22988

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The investigation of children with suspected inherited platelet disorders is challenging. The causes of mucocutaneous bleeding are many, and specialized testing for platelet disorders can be difficult to access or interpret. An algorithm developed for the investigation of suspected platelet disorders provides a sequential approach to evaluating both platelet function abnormalities and thrombocytopenia. Investigation begins with a clinical evaluation and laboratory testing that is generally available, including platelet counting, peripheral blood cell morphology, and aggregometry. Based on results of initial investigations, the algorithm recommends specialized testing for specific diagnoses, including flow cytometry, immunofluorescence microscopy, electron microscopy, and mutational analysis. Pediatr Blood Cancer 2011;56:975-983. (c) 2011 Wiley-Liss, Inc.

引用

页码：975 / 983

页数：9

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