Molecular Pathogenesis and the Possible Role of Mitochondrial Heteroplasmy in Thoracic Aortic Aneurysm

被引：2

作者：

Suslov, A. V. ^{[1
,2
]}

Afanasyev, M. A. ^{[1
]}

Degtyarev, P. A. ^{[2
]}

Chumachenko, P. V. ^{[1
]}

Ekta, M. Bagheri ^{[3
]}

Sukhorukov, V. N. ^{[1
,3
]}

Khotina, V. A. ^{[3
,4
]}

Yet, S. -F. ^{[5
]}

Sobenin, I. A. ^{[1
]}

Postnov, A. Yu ^{[1
,3
]}

机构：

[1] Natl Med Res Ctr Cardiol, Moscow 121552, Russia

[2] Sechenov Univ, Dept Human Anat, First Moscow State Med Univ, Moscow 119435, Russia

[3] Res Inst Human Morphol, Moscow 117418, Russia

[4] Inst Gen Pathol & Pathophysiol, Moscow 125315, Russia

[5] Natl Hlth Res Inst, Inst Cellular & Syst Med, 35 Keyan Rd, Zhunan Town 35053, Taiwan

来源：

LIFE-BASEL | 2021年 / 11卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

thoracic aortic aneurysm; mitochondrial genome; inflammation; metabolism; aortic dissection; cardiovascular diseases; SMOOTH-MUSCLE CELLS; SURGICAL PATHOLOGY; MOUSE MODEL; TGF-BETA; CIRCULATING FIBROCYTES; MTDNA HETEROPLASMY; OXIDATIVE STRESS; FIBROSIS; TISSUE; MECHANISMS;

D O I：

10.3390/life11121395

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thoracic aortic aneurysm (TAA) is a life-threatening condition associated with high mortality, in which the aortic wall is deformed due to congenital or age-associated pathological changes. The mechanisms of TAA development remain to be studied in detail, and are the subject of active research. In this review, we describe the morphological changes of the aortic wall in TAA. We outline the genetic disorders associated with aortic enlargement and discuss the potential role of mitochondrial pathology, in particular mitochondrial DNA heteroplasmy, in the disease pathogenesis.

引用

页数：14

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