Synergistic performance of cyclodextrin-agar hydrogels for ciprofloxacin delivery and antimicrobial effect

被引：56

作者：

Blanco-Fernandez, Barbara ^{[1
]}

Lopez-Viota, Margarita ^{[1
]}

Concheiro, Angel ^{[1
]}

Alvarez-Lorenzo, Carmen ^{[1
]}

机构：

[1] Univ Santiago de Compostela, Fac Farm, Dept Farm & Tecnol Farmaceut, Santiago De Compostela 15782, Spain

来源：

CARBOHYDRATE POLYMERS | 2011年 / 85卷 / 04期

关键词：

Marine polysaccharide; Cyclodextrin; Inclusion complexes; Antimicrobial drug; Chemically cross-linked hydrogels; Controlled release; RHEOLOGICAL CHARACTERIZATION; POLYSACCHARIDE HYDROGELS; RELEASE; BIODEGRADATION; NETWORKS; POLYMERS; DRUGS; GELS;

D O I：

10.1016/j.carbpol.2011.03.042

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Combination of cyclodextrins (CDs) and agar may render hydrogels that interact with drugs by forming inclusion complexes and/or ionic bonds. Hydroxypropyl-beta-cyclodextrin and methyl-beta-cyclodextrin (20%) in alkaline solutions containing or not agar (up to 1.5%) were cross-linked with ethyleneglycol diglycidylether at 50 degrees C. Agar increases hardness, compressibility and modulus of deformability, but does not interfere in the loading and release of a probe (3-methyl benzoic acid) with high affinity for CD. Agar notably promoted the loading of the zwitterion ciprofloxacin and endowed the hydrogels with ability to retain the drug in water medium. The release can be triggered by ions or changes in pH, leading to a 12-h sustained delivery. Loading and release profiles were compared to those of maltodextrin-based hydrogels, and the contribution of CDs and agar elucidated. Microbiological tests with Gram-negative and Gram-positive bacteria confirmed the suitability of the "green" CD-agar hydrogels for the development of drug delivery systems with tunable physical and drug loading/release properties. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：765 / 774

页数：10

共 57 条

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