Pathologic Correlation of Paramagnetic White Matter Lesions in Adult-Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

被引：7

作者：

Kim, Minkyeong ^{[1
]}

Lee, Hansol ^{[2
]}

Cho, Hyung Joon ^{[2
]}

Chun, Se Young ^{[3
]}

Shin, Jin-Hong ^{[1
,7
]}

Kim, Eun-Joo ^{[4
,7
]}

Ahn, Jae Woo ^{[5
]}

Huh, Gi Young ^{[5
,7
]}

Baek, Sun-Yong ^{[6
,7
]}

Lee, Jae-Hyeok ^{[1
,7
]}

机构：

[1] Pusan Natl Univ, Yangsan Hosp, Res Inst Convergence Biomed Sci & Technol, Dept Neurol, Yangsan, South Korea

[2] Ulsan Natl Inst Sci & Technol, Dept Biomed Engn, Ulsan, South Korea

[3] Ulsan Natl Inst Sci & Technol, Sch Elect & Comp Engn, Ulsan, South Korea

[4] Pusan Natl Univ Hosp, Dept Neurol, Busan, South Korea

[5] Pusan Natl Univ, Sch Med, Dept Forens Med, Yangsan, South Korea

[6] Pusan Natl Univ, Sch Med, Dept Anat, Yangsan, South Korea

[7] Pusan Natl Univ, Sch Med, Med Res Inst, Yangsan, South Korea

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2017年 / 76卷 / 11期

关键词：

Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia; Paramagnetic; Susceptibility-weighted imaging; White matter; NEUROAXONAL SPHEROIDS; CSF1R MUTATION; BRAIN-TISSUE; IRON; DISEASE; MRI; LEUKODYSTROPHY;

D O I：

10.1093/jnen/nlx086

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It has been proposed that susceptibility-weighted imaging is a sensitive magnetic resonance imaging (MRI) technique for identifying white matter (WM) pathologic changes involving demyelination and iron accumulation. We identified the tree silhouette-like configuration with a paramagnetic phase shift in the frontal subcortical WM lesions of 4 patients with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia who underwent 3T MRI. According to our postmortem 7T MRI and histologic correlation study to investigate the origin of the susceptibility-related phase contrast, changes in the subcortical WM architecture and central WM loss with the relative preservation of iron-rich U-fibers may contribute to the paramagnetic susceptibility.

引用

页码：924 / 928

页数：5

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