Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

被引：5
作者：
Moia, Riccardo [1 ,2 ]
Cittone, Micol Giulia [2 ,3 ]
Boggione, Paola [1 ,2 ]
Manfredi, Giulia Francesca [2 ,3 ]
Favini, Chiara [1 ,2 ]
Awikeh, Bassel [1 ,2 ]
Pedrinelli, Anita Rebecca [2 ,3 ]
Mahmoud, Abdurraouf Mokhtar [1 ,2 ]
Nicolosi, Maura [1 ,2 ]
Bellan, Mattia [2 ,3 ]
Sainaghi, Pier Paolo [2 ,3 ]
Pirisi, Mario [2 ,3 ]
Gaidano, Gianluca [1 ,2 ]
Patriarca, Andrea [1 ,2 ]
Rigamonti, Cristina [2 ,3 ]
机构：
[1] Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy
[2] Azienda Osped Univ Maggiore Carita, Novara, Italy
[3] Univ Piemonte Orientale, Dept Translat Med, Div Internal Med, Novara, Italy
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
关键词：
myeloproliferative neoplasms; spleen stiffness; JAK2; mutations; vibration-controlled transient elastography (VCTE); NGS; TRANSIENT ELASTOGRAPHY; PORTAL-HYPERTENSION; STIFFNESS; LIVER;
D O I：
10.3389/fonc.2021.777730
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells >= 10,000/mu l (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.
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页数：5
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