Stiffer Spleen Predicts Higher Bone Marrow Fibrosis and Higher JAK2 Allele Burden in Patients With Myeloproliferative Neoplasms

被引：8

作者：

Moia, Riccardo ^{[1
,2
]}

Cittone, Micol Giulia ^{[2
,3
]}

Boggione, Paola ^{[1
,2
]}

Manfredi, Giulia Francesca ^{[2
,3
]}

Favini, Chiara ^{[1
,2
]}

Awikeh, Bassel ^{[1
,2
]}

Pedrinelli, Anita Rebecca ^{[2
,3
]}

Mahmoud, Abdurraouf Mokhtar ^{[1
,2
]}

Nicolosi, Maura ^{[1
,2
]}

Bellan, Mattia ^{[2
,3
]}

Sainaghi, Pier Paolo ^{[2
,3
]}

Pirisi, Mario ^{[2
,3
]}

Gaidano, Gianluca ^{[1
,2
]}

Patriarca, Andrea ^{[1
,2
]}

Rigamonti, Cristina ^{[2
,3
]}

机构：

[1] Univ Piemonte Orientale, Dept Translat Med, Div Hematol, Novara, Italy

[2] Azienda Osped Univ Maggiore Carita, Novara, Italy

[3] Univ Piemonte Orientale, Dept Translat Med, Div Internal Med, Novara, Italy

来源：

FRONTIERS IN ONCOLOGY | 2021年 / 11卷

关键词：

myeloproliferative neoplasms; spleen stiffness; JAK2; mutations; vibration-controlled transient elastography (VCTE); NGS; TRANSIENT ELASTOGRAPHY; PORTAL-HYPERTENSION; STIFFNESS; LIVER;

D O I：

10.3389/fonc.2021.777730

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A total of 63 myeloproliferative neoplasms [MPN; 9 polycythemia vera (PV), 32 essential thrombocythemia (ET), and 22 myelofibrosis (MF)] underwent spleen stiffness (SS) measurement by vibration-controlled transient elastography equipped with a novel spleen-dedicated module. Higher SS values significantly correlated with grade 2-3 bone marrow (BM) fibrosis (p=0.035), with hemoglobin level <10 g/dl (p=0.014) and with white blood cells >= 10,000/mu l (p=0.008). Median SS was significantly higher in MF patients compared to ET and PV (p=0.015). SS also correlated with higher JAK2 variant allele frequency (p=0.02). This study identifies SS as a potential noninvasive tool that reflects BM fibrosis and the mutational burden in MPN.

引用

页数：5

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