Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period

被引：2

作者：

Baskal, Svetlana ^{[1
]}

Beckmann, Bibiana ^{[1
]}

Stahmer, Laura ^{[2
]}

Peter, Corinna ^{[3
]}

Bohnhorst, Bettina ^{[3
]}

Das, Anibh Martin ^{[2
]}

Tsikas, Dimitrios ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Toxicol, Core Unit Prote, Carl Neuberg Str 1, D-30625 Hannover, Germany

[2] Hannover Med Sch, Clin Pediat Kidney Liver & Metab Dis, D-30623 Hannover, Germany

[3] Hannover Med Sch, Clin Pediat Pneumol Allergol & Neonatol, D-30623 Hannover, Germany

来源：

AMINO ACIDS | 2022年 / 54卷 / 12期

关键词：

AGEs; Amino acids; Asymmetric dimethylarginine; Citrullination; Human breast milk; Oxidative stress; PTM; Sirtuins; QUANTIFICATION; IDENTIFICATION; HOMOARGININE;

D O I：

10.1007/s00726-022-03197-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We measured free and proteinic concentrations of native and modified amino acids from post-translational modifications (PTMs) and correlated them with the activity of SIRT1 and SIRT3 in the pellet and aqueous phases of human breast milk samples of ten lactating women during the neonatal period. SIRT1 and SIRT3 correlated directly with citrullination, asymmetric dimethylation and glycation of L-arginine, hydroxylation and glycation of L-lysine. SIRT1 and SIRT3 correlated inversely with the hydroxylation of L-proline. SIRT1 and SITR3 tended to correlate inversely with oxidative stress measured as malondialdehyde. Our study suggests that SIRT1 and SIRT3 may modulate PTMs in human breast milk cells.

引用

页码：1611 / 1619

页数：9

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