Synthesis of bicyclic aryl thiazolines with selective anti-proliferative effects on human cancer cell lines

被引：0

作者：

Singh, Rakesh K. ^{[1
]}

Lange, Thilo S. ^{[1
,2
]}

Kim, Kyu K. ^{[1
]}

Singh, Ajay P. ^{[3
]}

Hopson, Russell ^{[4
]}

Vorsa, Nicholi ^{[3
]}

Brard, Laurent ^{[1
]}

机构：

[1] Brown Univ, Women & Infants Hosp, Warren Alpert Med Sch,Program Womens Oncol, Dept Obstet & Gynecol,Div Gynecol Oncol,Mol Thera, Providence, RI 02905 USA

[2] Brown Univ, Div Biol & Med, Providence, RI 02912 USA

[3] Rutgers State Univ, Dept Plant Biol, New Brunswick, NJ 08901 USA

[4] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

LETTERS IN ORGANIC CHEMISTRY | 2008年 / 5卷 / 02期

关键词：

thiazolines; eschenmoser; cytotoxicity; neuroblastoma; ovarian cancer;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The novel synthesis of aryl thiazolines (ATZ) is described and structures established by COSY, HSQC, HMBC and NOESY experiments. Compounds DCL-ATZ and Me-ATZ displayed cytotoxic activities against a neuroblastoma, a platinum-resistant ovarian adenocarcinoma and a prostate adenocarcinoma cell line. Me-ATZ displayed differential anti-proliferative effects.

引用

页码：103 / 109

页数：7

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