Stem cells for treatment of liver fibrosis/cirrhosis: clinical progress and therapeutic potential

被引：50
作者：
Liu, Pinyan [1 ]
Mao, Yongcui [1 ]
Xie, Ye [1 ]
Wei, Jiayun [1 ]
Yao, Jia [1 ,2 ]
机构：
[1] Lanzhou Univ, Clin Med Coll 1, Lanzhou, Peoples R China
[2] Key Lab Biotherapy & Regenerat Med Gansu Prov, Lanzhou, Peoples R China
来源：
STEM CELL RESEARCH & THERAPY | 2022年 / 13卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Stem cells; Liver fibrosis; cirrhosis; Clinical trials; Cell therapy; Mechanism; MESENCHYMAL STROMAL CELLS; HEPATOCYTE-LIKE CELLS; HEPATIC DIFFERENTIATION; IN-VITRO; FIBROSIS ALLEVIATION; CO-TRANSPLANTATION; PROGENITOR CELLS; REGENERATION; CIRRHOSIS; ACTIVATION;
D O I：
10.1186/s13287-022-03041-5
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Cost-effective treatment strategies for liver fibrosis or cirrhosis are limited. Many clinical trials of stem cells for liver disease shown that stem cells might be a potential therapeutic approach. This review will summarize the published clinical trials of stem cells for the treatment of liver fibrosis/cirrhosis and provide the latest overview of various cell sources, cell doses, and delivery methods. We also describe the limitations and strengths of various stem cells in clinical applications. Furthermore, to clarify how stem cells play a therapeutic role in liver fibrosis, we discuss the molecular mechanisms of stem cells for treatment of liver fibrosis, including liver regeneration, immunoregulation, resistance to injury, myofibroblast repression, and extracellular matrix degradation. We provide a perspective for the prospects of future clinical implementation of stem cells.
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页数：20
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