An Ionic Liquid Containing L-Proline Moiety as Highly Efficient and Recyclable Chiral Organocatalyst for Michael Addition

被引：8

作者：

Li, Jiang ^{[1
,2
]}

Li, Xia Bing ^{[1
]}

Ma, Sha Sha ^{[1
]}

Liu, Juan ^{[1
]}

Li, Ben Hao ^{[1
]}

Li, Bao Lin ^{[1
]}

机构：

[1] Shaanxi Normal Univ, Sch Chem & Chem Engn, Key Lab, Minist Educ Med Resources & Nat Pharmaceut Chem, Xian 710062, Peoples R China

[2] Ningxia Med Univ, Sch Basic Med Sci, Dept Med Chem, Yinchuan 750004, Peoples R China

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2016年 / 37卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Michael addition; Chiral catalysis; Chiral ionic liquid; -Nitroalkenes; L-Proline; BIFUNCTIONAL ORGANOCATALYST; PYRROLIDINE-THIOUREA; SUPPORTED PROLINE; KETONES; ALDEHYDES; CATALYST;

D O I：

10.1002/bkcs.10848

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel chiral ionic liquid containing proline moiety was synthesized. It can be used as a highly efficient and recyclable chiral organocatalyst for Michael addition of cyclohexanone with (E)--nitroalkenes in methanol at room temperature. The Michael addition affords the corresponding products in satisfactory yields of isolated products (78-98%) with high diastereoselectivities and excellent enantioselectivities (up to 98% dr and up to 99% ee). The catalyst can be recycled up to five times without any decrease in yields and stereoselectivities.

引用

页码：1259 / 1264

页数：6

共 43 条

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