Variation of photon density distribution with system component within Intralipid emulsion

In order to recover distributions of optical parameters of underlining tissues utilizing backreflection optic tomography or diffuse reflectance spectroscopy for diagnostic proposes, trajectories of photons should be correctly estimated within tissue. Therefore, we have simulated the soft tissues with 1% Intralipid emulsion and have determined photon density distribution as a function of depth inside the Intralipid emulsions using laser light of wavelength 808 nm and two different detectors for different source-to-detector (S-D) separations. In this study we have shown difference in path distribution of the detected photons with two different detectors with different sensitivity for the same S-D separations in the Intralipid emulsions. This study has also shown that, the maximum penetration depth (MPD) of the detected photons is not an increasing function of the S-D separations. After reaching a maximum depth, the penetration depth decreases as S-D separation increases. (C) 2010 Elsevier GmbH. All rights reserved.