Asymmetric chlorination of 4-substituted pyrazolones catalyzed by natural cinchona alkaloid

被引：48

作者：

Bao, Xiaoze ^{[1
]}

Wei, Shiqiang ^{[1
]}

Zou, Liwei ^{[1
]}

He, Yuli ^{[1
]}

Xue, Fuzhao ^{[1
]}

Qu, Jingping ^{[1
]}

Wang, Baomin ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Pharmaceut Sci & Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 76期

基金：

中国国家自然科学基金;

关键词：

BETA-KETO-ESTERS; VICINAL TETRASUBSTITUTED STEREOCENTERS; ORGANOCATALYTIC ALPHA-CHLORINATION; CHIRAL PHOSPHORIC-ACID; ENANTIOSELECTIVE SYNTHESIS; CARBONYL-COMPOUNDS; MICHAEL ADDITION; STEREOCONTROLLED CONSTRUCTION; 3-SUBSTITUTED OXINDOLES; DICARBONYL-COMPOUNDS;

D O I：

10.1039/c6cc06236a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A natural quinidine-catalyzed asymmetric chlorination of 4-substituted pyrazolones is developed, affording products with a quaternary chiral chlorine-attached carbon centre in high yield with excellent enantio-selectivity. The low catalyst loading (1 mol%), broad substrate scope, and facile and valuable transformation of the product highlight the practical utility of this process.

引用

页码：11426 / 11429

页数：4

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