Glycomics-driven discoveries in schistosome research

被引：66
作者：
Hokke, Cornelis H.
Deelder, Andre M.
Hoffmann, Karl F.
Wuhrer, Manfred
机构：
[1] Leiden Univ, Med Ctr, Dept Parasitol, NL-2300 RC Leiden, Netherlands
[2] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England
来源：
EXPERIMENTAL PARASITOLOGY | 2007年 / 117卷 / 03期
关键词：
Schistosoma; glycoprotein; carbohydrate; host-parasite interaction; immunomodulation; antigen; glycome; glycan; lectin; CAA; circulating anodic antigen; CCA; circulating cathodic antigen; CD; cluster of differentiation; DC; dendritic cell; DC-SIGN; dendritic cell-specific intercellular adhesion molecule-grabbing non-integrin; HILIC; hydrophobic interaction liquid chromatography; KLH; keyhole limpet hemocyanin; LacNAc; N-acetyllactosamine; LC; liquid chromatography; Le(X); Lewis X; mAb; monoclonal antibody; MALDt-TOF; matrix assisted laser desorption ionisation-time of flight; MGL; macrophage galactose-binding lectin; MR; mannose receptor; MS; mass spectrometry; PNGase; peptide-N-glycosidase; SEA; soluble egg antigens; TLR; toll-like receptor;
D O I：
10.1016/j.exppara.2007.06.003
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Schistosome glycans and glycoconjugates play a prominent role in the parasite's biology, in particular in the interaction with the human host. A large amount of structural data regarding glycosylation of different schistosome life stages and glycoconjugate subsets has been collected in the last decade, but many significant gaps in our knowledge of the schistosomal glycome remain. Here we will present a concise review of the already available data guided by a selection of recently generated stage-specific glycan profiles, and discuss implications and prospects of glycomics studies of schistosomes. (C) 2007 Elsevier Inc. All rights reserved.
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页码：275 / 283
页数：9
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