The emerging role of the long non-coding RNA HOTAIR in breast cancer development and treatment

被引：90
作者：
Mozdarani, Hossein [1 ]
Ezzatizadeh, Vahid [1 ]
Parvaneh, Roghayeh [1 ]
机构：
[1] Tarbiat Modares Univ, Dept Med Genet, Fac Med Sci, Tehran, Iran
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2020年 / 18卷 / 01期
关键词：
HOTAIR; lncRNA; Normal development; Breast cancer; Therapeutic approaches; HUMAN CERVICAL-CANCER; LNCRNA HOTAIR; MESENCHYMAL TRANSITION; BIOLOGICAL BEHAVIORS; CELL-PROLIFERATION; DOWN-REGULATION; STEM-CELLS; EXPRESSION; MIGRATION; INVASION;
D O I：
10.1186/s12967-020-02320-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Despite considering vast majority of the transcribed molecules as merely noise RNA in the last decades, recent advances in the field of molecular biology revealed the mysterious role of long non-coding RNAs (lncRNAs), as a massive part of functional non-protein-coding RNAs. As a crucial lncRNA, HOX antisense intergenic RNA (HOTAIR) has been shown to participate in different processes of normal cell development. Aberrant overexpression of this lncRNA contributes to breast cancer progression, through different molecular mechanisms. In this review, we briefly discuss the structure of HOTAIR in the context of genome and impact of this lncRNA on normal human development. We subsequently summarize the potential role of HOTAIR overexpression on different processes of breast cancer development. Ultimately, the relationship of this lncRNA with different therapeutic approaches is discussed.
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页数：15
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