Endogenous interleukin-6 plays a crucial protective role in streptococcal toxic shock syndrome via suppression of tumor necrosis factor alpha production

被引：44
作者：
Diao, H
Kohanawa, M
机构：
[1] Hokkaido Univ, Inst Med Genet, Div Mol Immunol, Kita Ku, Sapporo, Hokkaido 0600815, Japan
[2] Hokkaido Univ, Dept Microbiol, Sch Med, Sapporo, Hokkaido 0600815, Japan
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 06期
关键词：
D O I：
10.1128/IAI.73.6.3745-3748.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
During a Streptococcus pyogenes infection in interleukin-6 (IL-6)-deficient mice, there is elevation of serum tumor necrosis factor alpha (TNF-alpha) levels, muscular necrosis, and death compared with infection of C57BL/6 mice. Anti-TNF-alpha monoclonal antibody treatment decreased mortality and muscular necrosis in the infected IL-6-deficient mice. These results suggest that IL-6 plays a crucial protective role via suppression of TNF-a production in S. pyogenes infection.
引用
收藏
页码：3745 / 3748
页数：4
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