The association of β-arrestin2 polymorphisms with response to antidepressant treatment in depressed patients

被引：7
|
作者：
Petit, Anne-Cecile [1 ,2 ]
El Asmar, Khalil [1 ]
David, Denis J. [3 ]
Gardier, Alain M. [3 ]
Becquemont, Laurent [1 ,4 ]
Feve, Bruno [5 ,6 ,7 ]
Verstuyft, Celine [1 ,8 ,9 ]
Corruble, Emmanuelle [1 ,2 ]
机构：
[1] Univ Paris Sud, INSERM, CESP UMR S1178, Equipe Depress & Antidepresseurs,Fac Med, Le Kremlin Bicetre, France
[2] Hop Bicetre, AP HP, Serv Psychiat, Le Kremlin Bicetre, France
[3] Univ Paris Sud, Univ Paris Saclay, CESP UMR S1178, Equipe Depress & Antidepresseurs,Fac Pharm,INSERM, F-92296 Chatenay Malabry, France
[4] Ctr Rech Clin Paris Sud, AP HP, Le Kremlin Bicetre, France
[5] Pierre & Marie Curie Univ Paris 6, Sorbonne Univ, St Antoine Hosp, INSERM,St Antoine Res Ctr, Paris, France
[6] Hosp Univ Inst, ICAN, Paris, France
[7] St Antoine Hosp, AP HP, Dept Endocrinol, Paris, France
[8] AP HP, Serv Genet Mol Pharmacogenet & Hormonol, Le Kremlin Bicetre, France
[9] Hop Bicetre, AP HP, Ctr Ressources Biol Paris Sud, Le Kremlin Bicetre, France
来源：
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2018年 / 81卷
关键词：
Pharmacogenetics; Antidepressant; Major depressive disorder; Beta-arrestin; ARRB2; BETA-ARRESTINS; DEPENDENCE; LEUKOCYTES; RECEPTORS; PATHWAYS; DISORDER; BRAIN; CELLS; MODEL; GENE;
D O I：
10.1016/j.pnpbp.2017.10.006
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The study of genetic polymorphisms involved in antidepressants (AD) response is essential to provide a personalized medicine approach in the field of depression. beta-arrestin 2 (ARRB2) is a candidate gene in the pharmacogenetics of AD as it is involved in the signaling cascade downstream of numerous neurotransmitter receptors. We investigated the association between five ARRB2 single nucleotide polymorphisms (SNPs): rs1045280, rs2036657, rs4790694, rs3786047 and rs452246, and response to AD treatment in a sample of 569 patients with a major depressive episode treated for 6 months. We show that GG/GT patients for rs4522461 (n = 534) and AA/AC patients for rs4790694 (n = 244) have a lower response to AD than other genotype groups (HDRS score of 10.9 vs 8.0 after 6 months, multivariate analysis: p = 0.03; 12.2 vs 9.6, p = 0.02, respectively). These data provide additional evidence that beta-arrestin 2 is a regulator of intracellular signal transduction processes involved in AD treatment.
引用
收藏
页码：74 / 79
页数：6
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