The Relation of Diabetes, Impaired Fasting Blood Glucose, and Insulin Resistance to Left Ventricular Structure and Function in African Americans The Jackson Heart Study

被引：15

作者：

Fox, Ervin R. ^{[1
]}

Sarpong, Daniel F. ^{[2
]}

Cook, Joe C. ^{[1
]}

Samdarshi, Tandaw E. ^{[1
]}

Nagarajarao, Harsha S. ^{[1
]}

Liebson, Philip R. ^{[3
]}

Sims, Mario ^{[1
]}

Howard, George ^{[4
]}

Garrison, Robert ^{[1
]}

Taylor, Herman A., Jr. ^{[1
]}

机构：

[1] Univ Mississippi Sch Med, Jackson, MS 38677 USA

[2] Jackson State Univ, Jackson, MS USA

[3] Rush Univ Med Ctr, Chicago, IL USA

[4] Univ Alabama, Birmingham, AL USA

来源：

DIABETES CARE | 2011年 / 34卷 / 02期

基金：

美国国家卫生研究院;

关键词：

ADULTS;

D O I：

10.2337/dc10-0838

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-We assessed the relation of diabetes and insulin resistance (IR) on left ventricular (LV) structure and function in African Americans. RESEARCH DESIGN AND METHODS-Among those receiving echocardiograms in cycle 1 of the Jackson Heart Study, we assessed the sex-specific relation of fasting blood glucose (FBG), diabetes, and IR to LV structure and function, adjusting for age, systolic blood pressure, antihypertensive medications, and BMI. RESULTS-Among 2,399 participants, LV mass index (P(women) = 0.0002 and P(men) = 0.02), posterior wall thickness (P(women) = 0.01 and P(men) = 0.05), and interventricular septal wall thickness (P(women) = 0.01) were related to FBG categories. Among those with normal FBG and no diabetes, concentric remodeling and low ejection fraction in women and LV mass index and posterior wall thickness in men were related to IR. CONCLUSIONS-In the largest study of its kind in a community-based cohort of African Americans, we found a relation of FBG category and IR to LV structure and function.

引用

页码：507 / 509

页数：3

共 14 条

[1] Comparison of cardiac structure and function in American Indians with and without the metabolic syndrome (The Strong Heart study) [J].