Bifidobacterium lactis BB-12 Attenuates Macrophage Aging Induced by D-Galactose and Promotes M2 Macrophage Polarization

被引：15

作者：

Zhang, Da-yong ^{[1
]}

Pan, Zheng-yang ^{[1
]}

Yu, Xiong-kai ^{[1
]}

Chen, Yi-fan ^{[1
]}

Gao, Chen-hao ^{[1
]}

Yang, Yu-tian ^{[1
]}

Jiang, Xue-fan ^{[2
,3
]}

Li, Na ^{[1
]}

Pan, Jian-ping ^{[1
]}

机构：

[1] Zhejiang Univ City Coll, Sch Med, Dept Clin Med, Hangzhou 310015, Peoples R China

[2] Zhejiang Prov Peoples Hosp, Dept Otorhinolaryngol, Hangzhou 310014, Zhejiang, Peoples R China

[3] Hangzhou Med Coll, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2019年 / 2019卷

基金：

中国国家自然科学基金;

关键词：

ACTIVATION; AGE; P16(INK4A); INFLAMMATION; SUPERNATANT; COMPONENTS; CULTURE; YOGURT; CELLS;

D O I：

10.1155/2019/4657928

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunosenescence comprises a set of dynamic changes occurring in innate and adaptive immune systems, and macrophage aging plays an important role in innate and adaptive immunosenescence. However, function and polarization changes in aging macrophages have not been fully evaluated, and no effective method for delaying macrophage senescence is currently available. The results of this study reveal that D-galactose (D-gal) can promote J774A.1 macrophage senescence and induce macrophage M1 polarization differentiation. Bifidobacterium lactis BB-12 can significantly inhibit J774A.1 macrophage senescence induced by D-gal. IL-6 and IL-12 levels in the BB-12 groups remarkably decreased compared with that in the D-gal group, and the M2 marker, IL-10, and Arg-1 mRNA levels increased in the BB-12 group. BB-12 inhibited the expression of p-signal transducer and activator of transcription 1 (STAT1) and promoted p-STAT6 expression. In summary, the present study indicates that BB-12 can attenuate the J774A.1 macrophage senescence and induce M2 macrophage polarization, thereby indicating the potential of BB-12 to slow down immunosenescence and inflamm-aging.

引用

页数：12

共 56 条

[11] Cathelicidin-WA polarizes E. coli K88-induced M1 macrophage to M2-like macrophage in RAW264.7 cells [J].

Chen, Shan ;

Lu, Zeqing ;

Wang, Fengqin ;

Wang, Yizhen .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 54 :52-59

[12] p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages [J].

Cudejko, Celine ;

Wouters, Kristiaan ;

Fuentes, Lucia ;

Hannou, Sarah Anissa ;

Paquet, Charlotte ;

Bantubungi, Kadiombo ;

Bouchaert, Emmanuel ;

Vanhoutte, Jonathan ;

Fleury, Sebastien ;

Remy, Patrick ;

Tailleux, Anne ;

Chinetti-Gbaguidi, Giulia ;

Dombrowicz, David ;

Staels, Bart ;

Paumelle, Rejane .

BLOOD, 2011, 118 (09) :2556-2566

[13] Changes with age in peritoneal macrophage functions. Implication of leukocytes in the oxidative stress of senescence [J].

De la Fuente, M ;

Hernanz, A ;

Guayerbas, N ;

Alvarez, P ;

Alvarado, C .

CELLULAR AND MOLECULAR BIOLOGY, 2004, 50 :683-690

[14] Physalin D regulates macrophage M1/M2 polarization via the STAT1/6 pathway [J].

Ding, Ning ;

Wang, Yuxing ;

Dou, Ce ;

Liu, Feila ;

Guan, Ge ;

Wei, Keyu ;

Yang, Jingyuan ;

Yang, Mingcan ;

Tan, Ju ;

Zeng, Wen ;

Zhu, Chuhong .

JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (06) :8788-8796

[15] Downregulation of the tumour suppressor p16INK4A contributes to the polarisation of human macrophages toward an adipose tissue macrophage (ATM)-like phenotype [J].

Fuentes, L. ;

Wouters, K. ;

Hannou, S. A. ;

Cudejko, C. ;

Rigamonti, E. ;

Mayi, T. H. ;

Derudas, B. ;

Pattou, F. ;

Chinetti-Gbaguidi, G. ;

Staels, B. ;

Paumelle, R. .

DIABETOLOGIA, 2011, 54 (12) :3150-3156

[16] RETRACTED: Osteopontin and Protein Kinase C Regulate PDLIM2 Activation and STAT1 Ubiquitination in LPS-treated Murine Macrophages (Retracted Article) [J].

Guo, Hongtao ;

Mi, Zhiyong ;

Bowles, Dawn E. ;

Bhattacharya, Syamal D. ;

Kuo, Paul C. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (48) :37787-37796

[17] Aging of mice is associated with p16(Ink4a)- and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells [J].

Hall, Brandon M. ;

Balan, Vitaly ;

Gleiberman, Anatoli S. ;

Strom, Evguenia ;

Krasnov, Peter ;

Virtuoso, Lauren P. ;

Rydkina, Elena ;

Vujcic, Slavoljub ;

Balan, Karina ;

Gitlin, Ilya ;

Leonova, Katerina ;

Polinsky, Alexander ;

Chernova, Olga B. ;

Gudkov, Andrei V. .

AGING-US, 2016, 8 (07) :1294-1315

[18] Impaired GATA3-dependent chromatin remodeling and Th2 cell differentiation leading to attenuated allergic airway inflammation in aging mice [J].

Hasegawa, A ;

Miki, T ;

Hosokawa, H ;

Hossain, MB ;

Shimizu, C ;

Hashimoto, K ;

Kimura, MY ;

Yamashita, M ;

Nakayama, T .

JOURNAL OF IMMUNOLOGY, 2006, 176 (04) :2546-2554

[19] Supernatant of Bifidobacterium breve induces dendritic cell maturation, activation, and survival through a Toll-like receptor 2 pathway [J].

Hoarau, C ;

Lagaraine, C ;

Martin, L ;

Velge-Roussel, F ;

Lebranchu, Y .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (03) :696-702

[20] Age-Related Differences in Percentages of Regulatory and Effector T Lymphocytes and Their Subsets in Healthy Individuals and Characteristic STAT1/STAT5 Signalling Response in Helper T Lymphocytes [J].

Holcar, Marija ;

Goropevsek, Ales ;

Ihan, Alojz ;

Avcin, Tadej .

JOURNAL OF IMMUNOLOGY RESEARCH, 2015, 2015

← 1 2 3 4 5 6 →