The prevention of gastric cancer by Helicobacter pylori eradication

被引:16
作者
Argueta, Erick A. [1 ]
Moss, Steven F. [1 ]
机构
[1] Brown Univ, Div Gastroenterol, Alpert Med Sch, Providence, RI USA
关键词
cancer screening; gastric cancer; H; pylori;
D O I
10.1097/MOG.0000000000000777
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Purpose of review Gastric cancer remains one of the most common causes of death globally. Increasing evidence suggests that many gastric cancer cases can be prevented by eradicating its most important etiological agent, Helicobacter pylori. Using the search terms 'H. pylori' and 'gastric cancer' we reviewed the scientific literature regarding the association between H. pylori and gastric cancer published from 1 January 2020 to 30 May 2021. We review the most important articles relevant to the clinical issues regarding H. pylori eradication for gastric cancer prevention. Recent findings In randomized trials, eradication of H. pylori is associated with an approximately 50% reduction in sporadic gastric cancer. A similar benefit was observed when screening first-degree relatives of gastric cancer cases, after resection of early gastric cancer to prevent metachronous neoplasia, and in population-based screen and treatment programs in areas of high H. pylori and gastric cancer prevalence. Even in relatively low gastric cancer countries such as the United States, gastric cancer may potentially be avoided by screening for H. pylori, especially among minority groups who are at greatest risk. Gastric cancer is preventable, at least in part, by H. pylori eradication. Ongoing screening trials will help determine whether population-based H. pylori screening programs are feasible and cost-effective. Their results are likely to differ according to H. pylori and gastric cancer prevalence rates.
引用
收藏
页码:625 / 630
页数:6
相关论文
共 33 条
[1]   Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035 [J].
Arnold, Melina ;
Park, Jin Young ;
Camargo, M. Constanza ;
Lunet, Nuno ;
Forman, David ;
Soerjomataram, Isabelle .
GUT, 2020, 69 (05) :823-829
[2]  
Berice B, 2021, MEDICINES, V8
[3]  
BRAY F, 2018, CA-CANCER J CLIN, V68, P394, DOI [DOI 10.3322/caac.20115, DOI 10.3322/CAAC.21492]
[4]   Effectiveness of one-time endoscopic screening programme in prevention of upper gastrointestinal cancer in China: a multicentre population-based cohort study [J].
Chen, Ru ;
Liu, Yong ;
Song, Guohui ;
Li, Bianyun ;
Zhao, Deli ;
Hua, Zhaolai ;
Wang, Xinzheng ;
Li, Jun ;
Hao, Changqing ;
Zhang, Liwei ;
Liu, Shuzheng ;
Wang, Jialin ;
Zhou, Jinyi ;
Zhang, Yongzhen ;
Li, Bo ;
Li, Yanyan ;
Feng, Xiang ;
Li, Lin ;
Dong, Zhiwei ;
Wei, Wenqiang ;
Wang, Guiqi .
GUT, 2021, 70 (02) :251-260
[5]   Mass eradication of Helicobacter pylori to reduce gastric cancer incidence and mortality: a long-term cohort study on Matsu Islands [J].
Chiang, Tsung-Hsien ;
Chang, Wei-Jung ;
Chen, Sam Li-Sheng ;
Yen, Amy Ming-Fang ;
Fann, Jean Ching-Yuan ;
Chiu, Sherry Yueh-Hsia ;
Chen, Yi-Ru ;
Chuang, Shu-Ling ;
Shieh, Chun-Fu ;
Liu, Cheng-Ying ;
Chiu, Han-Mo ;
Chiang, Hung ;
Shun, Chia-Tung ;
Lin, Ming-Wei ;
Wu, Ming-Shiang ;
Lin, Jaw-Town ;
Chan, Chang-Chuan ;
Graham, David Y. ;
Chen, Hsiu-Hsi ;
Lee, Yi-Chia .
GUT, 2021, 70 (02) :243-250
[6]   Family History of Gastric Cancer and Helicobacter pylori Treatment [J].
Choi, Ii Ju ;
Kim, Chan Gyoo ;
Lee, Jong Yeul ;
Kim, Young-, II ;
Kook, Myeong-Cherl ;
Park, Boram ;
Joo, Jungnam .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 382 (05) :427-436
[7]   Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer [J].
Choi, Il Ju ;
Kook, Myeong-Cherl ;
Kim, Young-Il ;
Cho, Soo-Jeong ;
Lee, Jong Yeul ;
Kim, Chan Gyoo ;
Park, Boram ;
Nam, Byung-Ho .
NEW ENGLAND JOURNAL OF MEDICINE, 2018, 378 (12) :1085-1095
[8]   Exploring the interactions between Helicobacter pylori (Hp) infection and other risk factors of gastric cancer: A pooled analysis in the Stomach cancer Pooling (StoP) Project [J].
Collatuzzo, Giulia ;
Pelucchi, Claudio ;
Negri, Eva ;
Lopez-Carrillo, Lizbeth ;
Tsugane, Shoichiro ;
Hidaka, Akihisa ;
Hamada, Gerson Shigueaki ;
Hernandez-Ramirez, Raul Ulises ;
Lopez-Cervantes, Malaquias ;
Malekzadeh, Reza ;
Pourfarzi, Farhad ;
Mu, Lina ;
Zhang, Zuo-Feng ;
Lunet, Nuno ;
La Vecchia, Carlo ;
Boffetta, Paolo .
INTERNATIONAL JOURNAL OF CANCER, 2021, 149 (06) :1228-1238
[9]   Ethnic Disparities in Gastric Cancer Presentation and Screening Practice in the United States: Analysis of 1997-2010 Surveillance, Epidemiology, and End Results-Medicare Data [J].
Florea, Ana ;
Brown, Heidi E. ;
Harris, Robin B. ;
Oren, Eyal .
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2019, 28 (04) :659-665
[10]   Helicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis [J].
Ford, Alexander Charles ;
Yuan, Yuhong ;
Moayyedi, Paul .
GUT, 2020, 69 (12) :2113-2121