18F-NaF and 18F-FDG as molecular probes in the evaluation of atherosclerosis

被引：109

作者：

McKenney-Drake, Mikaela L. ^{[1
]}

Moghbel, Mateen C. ^{[2
]}

Paydary, Koosha ^{[3
]}

Alloosh, Mouhamad ^{[4
]}

Houshmand, Sina ^{[3
]}

Moe, Sharon ^{[5
,6
]}

Salavati, Ali ^{[3
,7
]}

Sturek, Jeffrey M. ^{[8
]}

Territo, Paul R. ^{[9
]}

Weaver, Connie ^{[10
]}

Werner, Thomas J. ^{[3
]}

Hoilund-Carlsen, Poul Flemming ^{[11
]}

Sturek, Michael ^{[4
]}

Alavi, Abass ^{[3
]}

机构：

[1] Butler Univ, Dept Hlth Sci, Indianapolis, IN 46208 USA

[2] Stanford Univ, Dept Radiol, Med Ctr, Stanford, CA 94305 USA

[3] Hosp Univ Penn, Dept Radiol, 3400 Spruce St, Philadelphia, PA 19104 USA

[4] Indiana Univ Sch Med, Dept Cellular & Integrat Physiol, Indianapolis, IN 46202 USA

[5] Indiana Univ Sch Med, Dept Med, Indianapolis, IN 46202 USA

[6] Richard L Roudebush Vet Adm Med Ctr, Indianapolis, IN USA

[7] Univ Minnesota, Dept Radiol, Minneapolis, MN 55455 USA

[8] Univ Virginia, Dept Med, Charlottesville, VA USA

[9] Indiana Univ Sch Med, Dept Radiol & Imaging Sci, Indianapolis, IN 46202 USA

[10] Purdue Univ, Dept Nutr Sci, W Lafayette, IN 47907 USA

[11] Odense Univ Hosp, Dept Nucl Med, Odense, Denmark

来源：

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2018年 / 45卷 / 12期

关键词：

Atherosclerosis; F-18-FDG; F-18-NaF; Calcification; Global assessment of cardiac disease; Cardiovascular disease quantification; POSITRON-EMISSION-TOMOGRAPHY; CAROTID PLAQUE INFLAMMATION; 18F-SODIUM FLUORIDE UPTAKE; LARGE ARTERIES; VASCULAR CALCIFICATION; METABOLIC SYNDROME; CORONARY-ARTERIES; LOW-CARBOHYDRATE; RISK-FACTORS; FDG UPTAKE;

D O I：

10.1007/s00259-018-4078-0

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The early detection of atherosclerotic disease is vital to the effective prevention and management of life-threatening cardiovascular events such as myocardial infarctions and cerebrovascular accidents. Given the potential for positron emission tomography (PET) to visualize atherosclerosis earlier in the disease process than anatomic imaging modalities such as computed tomography (CT), this application of PET imaging has been the focus of intense scientific inquiry. Although F-18-FDG has historically been the most widely studied PET radiotracer in this domain, there is a growing body of evidence that F-18-NaF holds significant diagnostic and prognostic value as well. In this article, we review the existing literature on the application of F-18-FDG and F-18-NaF as PET probes in atherosclerosis and present the findings of original animal and human studies that have examined how well F-18-NaF uptake correlates with vascular calcification and cardiovascular risk.

引用

页码：2190 / 2200

页数：11

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