Identification of a Valuable Kinetic Process in Copper-Catalyzed Asymmetric Allylic Alkylation

被引：39

作者：

Langlois, Jean-Baptiste ^{[1
]}

Alexakis, Alexandre ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, Quai Ernest Ansermet 30, CH-1211 Geneva, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 08期

基金：

新加坡国家研究基金会; 瑞士国家科学基金会;

关键词：

alkylation; allylic compounds; asymmetric catalysis; copper; Grignard reagents; DOUBLE-BOND CONFIGURATION; CROSS-COUPLING REACTIONS; GRIGNARD-REAGENTS; ENANTIOSELECTIVE SYNTHESIS; ORGANOCOPPER REAGENTS; DIALKYLZINC REAGENTS; HOMOALLYLIC ALCOHOLS; CONJUGATE ADDITION; MURAHASHI METHOD; DERIVATIVES;

D O I：

10.1002/anie.201005373

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Copper bottomed: The application of a previously described process of dynamic kinetic asymmetric transformation to acyclic substrates allowed the identification of a relevant kinetic process in the title reaction (see scheme; CuTC= copper(I) thiophencarboxylate, Naphth= naphthyl). The optimization of the reaction conditions and generality of the method, as well as mechanistic considerations are disclosed. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1877 / 1881

页数：5

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