Physicochemical and Biological Properties of Oxovanadium(IV), Cobalt(II) and Nickel(II) Complexes with Oxydiacetate Anions

被引：18
|
作者：
Wyrzykowski, Dariusz [1 ]
Kloska, Anna [2 ]
Pranczk, Joanna [1 ]
Szczepanska, Aneta [2 ]
Tesmar, Aleksandra [1 ]
Jacewicz, Dagmara [1 ]
Pilarski, Boguslaw [3 ]
Chmurzynski, Lech [1 ]
机构：
[1] Univ Gdansk, Fac Chem, PL-80308 Gdansk, Poland
[2] Univ Gdansk, Fac Biol, PL-80308 Gdansk, Poland
[3] Cerko Sp Zoo SP K, PL-81451 Gdynia, Poland
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2015年 / 164卷 / 01期
关键词：
Oxydiacetate complexes; Cytoprotective activity; Antimicrobial activity; Potentiometric titration; Conductometric titration; Stability constant; BINARY SOLVENT MIXTURES; DIMETHYLSULFOXIDE WATER MIXTURES; X-RAY CHARACTERIZATION; CRYSTAL-STRUCTURES; CONCENTRATION DEPENDENCE; ELECTROLYTE CONDUCTANCE; DIMETHYL-SULFOXIDE; PITTS TREATMENTS; METAL-COMPLEXES; FUOSS-ONSAGER;
D O I：
10.1007/s12011-014-0170-x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The potentiometric and conductometric titration methods have been used to characterize the stability of series of VO(IV)-, Co(II)- and Ni(II)-oxydiacetato complexes in DMSO-water solutions containing 0-50 % (v/v) DMSO. The influence of DMSO as a co-solvent on the stability of the complexes as well as the oxydiacetic acid was evaluated. Furthermore, the reactivity of the complexes towards superoxide free radicals was assessed by employing the nitro blue tetrazolium (NBT) assay. The biological properties of the complexes were investigated in relation to their cytoprotective activity against the oxidative damage generated exogenously by using hydrogen peroxide in the Human Dermal Fibroblasts adult (HDFa) cell line as well as to their antimicrobial activity against the bacteria (Bacillus subtilis, Escherichia coli, Enterococcus faecalis, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis). The relationship between physicochemical and biological properties of the complexes was discussed.
引用
收藏
页码：139 / 149
页数：11
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