Detection of rat hepatitis E virus in wild Norway rats (Rattus norvegicus) and Black rats (Rattus rattus) from 11 European countries

被引：64

作者：

Ryll, Rene ^{[1
]}

Bernstein, Samuel ^{[1
]}

Heuser, Elisa ^{[1
]}

Schlegel, Mathias ^{[1
,24
]}

Dremsek, Paul ^{[1
,25
]}

Zumpe, Maxi ^{[1
,26
]}

Wolf, Sandro ^{[2
,27
]}

Pepin, Michel ^{[3
]}

Bajomi, Daniel ^{[4
]}

Muller, Gabi ^{[5
]}

Heiberg, Ann-Charlotte ^{[6
]}

Spahr, Carina ^{[7
]}

Lang, Johannes ^{[8
]}

Groschup, Martin H. ^{[1
]}

Ansorge, Hermann ^{[9
]}

Freise, Jona ^{[10
]}

Guenther, Sebastian ^{[11
]}

Baert, Kristof ^{[12
]}

Ruiz-Fons, Francisco ^{[13
]}

Pikula, Jiri ^{[14
,15
]}

Knap, Natasa ^{[16
]}

Tsalcrnakidis, Ioannis ^{[17
]}

Dovas, Chrysostomos ^{[18
]}

Zanet, Stefania ^{[19
]}

Imholt, Christian ^{[20
]}

Heckel, Gerald ^{[21
,22
]}

Johne, Reimar ^{[7
]}

Ulrich, Rainer G. ^{[1
,23
]}

机构：

[1] Inst Novel & Emerging Infect Dis, Friedrich Loeffier Inst, Sudufer 10, D-17493 Greifswald, Germany

[2] Tech Univ Dresden, Inst Microbiol, Zellescher Weg 20b, D-01217 Dresden, Germany

[3] Univ Lyon 1, VetagroSup Microbiol Immu Pathol Infect, CIRI, Equipe VIRPATH, 1 Ave Bourgelat, F-69280 Marcy Letoile, France

[4] Badbolna Bio Ltd, Szallais 6, H-1107 Budapest, Hungary

[5] Umwelt & Gesundheitsschutz Zurich, Stadt Zurich, Walchestr 31, CH-8021 Zurich, Switzerland

[6] AC Heiberg Radgivning, Amosevej 69, Morkov 4440, Denmark

[7] German Fed Inst Risk Assessment, Max Dohrn Str 8-10, D-10589 Berlin, Germany

[8] Justus Liebig Univ Giessen, Working Grp Wildlife Biol, Leihgesterner Weg 217, D-35392 Giessen, Germany

[9] Senckenberg Museum Nat Hist, Museum 1, D-02826 Gorlitz, Germany

[10] Niedersachs Landesamt Verbraucherschutz & Lebensm, Fachbereich Schadlingsbekampfung, Task Force Veterinarwesen, Roverskamp 5, D-26203 Wardenburg, Germany

[11] Free Univ Berlin, Vet Fac, Inst Microbiol & Epizoot, Robert von Ostertag Str 7-13, D-14163 Berlin, Germany

[12] Res Grp Wildlife Management, Res Inst Nat & Forest INBO, Brussels, Belgium

[13] CSIC, UCLM, JCCCM, Spanish Wildlife Res Inst IREC, Ronda Toledo 12, Ciudad Real 13071, Spain

[14] Univ Vet & Pharmaceut Sci Brno, Dept Ecol & Dis Game Fish & Bees, Brno, Czech Republic

[15] Univ Vet & Pharmaceut Sci, CEITEC, Cent European Inst Technol, Brno, Czech Republic

[16] Inst Microbiol & Immunol, Fac Med, Zaloska 4, Ljubljana 1000, Slovenia

[17] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Vet Med, Lab Parasitol & Parasit Dis, Thessaloniki, Greece

[18] Aristotle Univ Thessaloniki, Fac Hlth Sci, Sch Vet Med, Diagnost Lab, Thessaloniki, Greece

[19] Univ Turin, Dipartimento Sci Vet Largo Paolo Braccini, 2 Gia Via L DaVinci 44, I-10095 Grugliasco, TO, Italy

[20] Inst Plant Protect Hort & Forestry Vertebrate Res, Fed Res Ctr Cultivated Plants, Julius Kuhn Inst, D-48161 Munster, Germany

[21] Univ Bern, Inst Ecol & Evolut, Baltzerstr 6, CH-3012 Bern, Switzerland

[22] Quartier Sorge Batiment Genopode, Swiss Inst Bioinformat, CH-1015 Lausanne, Switzerland

[23] German Ctr Infect Res DZIF, Partner Site Hamburg Luebeck Borstel Insel Riems, Braunschweig, Germany

[24] Seramun Diagnost GmbH, D-15754 Heidesee, Germany

[25] Labor Doz DDr Stefan Mustafa, A-1030 Vienna, Austria

[26] Univ Med Greifswald, Pediat Hematol & Oncol, Ferdinand Sauerbruch Str, D-17475 Greifswald, Germany

[27] Labor Ostsachsen, Bremer Str 57, D-01067 Dresden, Germany

来源：

VETERINARY MICROBIOLOGY | 2017年 / 208卷

关键词：

Hepeviridae; Hepatitis E virus; Genotype; 3; Norway rat; Black rat; Europe; CROSS-SPECIES INFECTION; GENOTYPE; 3; SUSCEPTIBILITY; PREVALENCE; GENOME; STRAIN;

D O I：

10.1016/j.vetmic.2017.07.001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rat hepatitis E virus (HEV) is genetically only distantly related to hepeviruses found in other mammalian reservoirs and in humans. It was initially detected in Norway rats (Rattus norvegicus) from Germany, and subsequently in rats from Vietnam, the USA, Indonesia, China, Denmark and France. Here, we report on a molecular survey of Norway rats and Black rats (Rattus rattus) from 12 European countries for ratHEV and human pathogenic hepeviruses. RatHEV-specific real-time and conventional RT-PCR investigations revealed the presence of ratHEV in 63 of 508 (12.4%) rats at the majority of sites in 11 of 12 countries. In contrast, a real-time RT-PCR specific for human pathogenic HEV genotypes 1-4 and a nested broad-spectrum (NBS) RT-PCR with subsequent sequence determination did not detect any infections with these genotypes. Only in a single Norway rat from Belgium a rabbit HEV-like genotype 3 sequence was detected. Phylogenetic analysis indicated a clustering of all other novel Norway and Black rat-derived sequences with ratHEV sequences from Europe, the USA and a Black rat-derived sequence from Indonesia within the proposed ratHEV genotype 1. No difference in infection status was detected related to age, sex, rat species or density of human settlements and zoological gardens. In conclusion, our investigation shows a broad geographical distribution of ratHEV in Norway and Black rats from Europe and its presence in all settlement types investigated.

引用

页码：58 / 68

页数：11

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