A placebo-controlled trial of insulin-like growth factor-I in amyotrophic lateral sclerosis

被引：275

作者：

Borasio, GD

Robberecht, W

Leigh, PN

Emile, J

Guiloff, RJ

Jerusalem, F

Silani, V

Vos, PE

Wokke, JHJ

Dobbins, T

机构：

[1] Univ Munich, Dept Neurol, D-80539 Munich, Germany

[2] Katholieke Univ Leuven, Dept Neurol, B-3001 Leuven, Belgium

[3] Inst Psychiat, Dept Clin Neurosci, London, England

[4] Univ London Kings Coll, Sch Med & Dent, London, England

[5] Univ Amsterdam, Acad Med Ctr, Lab Expt Neurol, NL-1105 AZ Amsterdam, Netherlands

[6] Univ Angers, Med Ctr, Dept Neurol B, Angers, France

[7] Univ Bonn, Dept Neurol, D-5300 Bonn, Germany

[8] Charing Cross Hosp, Neuromuscular Unit, London, England

[9] Univ Milan, IRCCS, Osped Maggiore, Dept Neurol, I-20122 Milan, Italy

[10] Univ Utrecht, Div Neuromuscular Dis, NL-3508 TC Utrecht, Netherlands

[11] Cephalon Inc, W Chester, PA USA

来源：

NEUROLOGY | 1998年 / 51卷 / 02期

关键词：

D O I：

10.1212/WNL.51.2.583

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To test the safety and efficacy of recombinant human insulin-like growth factor-I (rhIGF-I) in ALS, 183 patients from eight European centers were randomized to receive double-blind placebo (n = 59) or rhIGF-I 0.1 mg/kg/day (n = 124) subcutaneously for 9 months. At study completion, the primary efficacy outcome measure (change in disease progression as assessed by the Appel ALS rating scale) showed no significant difference between treatment groups. RhIGF-I appeared to be safe and well-tolerated.

引用

页码：583 / 586

页数：4

共 11 条

[11] A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis [J].

Miller, RG ;

Petajan, JH ;

Bryan, WW ;

Armon, C ;

Barohn, RJ ;

Goodpasture, JC ;

Hoagland, RJ ;

Parry, GJ ;

Ross, MA ;

Stromatt, SC ;

Belsh, JM ;

Buchman, AS ;

Donofrio, PD ;

Eisen, AA ;

Gan, RA ;

Gutmann, L ;

Horowitz, SH ;

Jackson, WS ;

Johnston, WS ;

Kelly, JJ ;

Malta, E ;

Mandler, RN ;

Massey, JM ;

McGuire, D ;

Newman, DS ;

Pascuzzi, RM ;

Phillips, LH ;

Ravits, JM ;

Rivner, MH ;

Rubin, M ;

Russo, LS ;

Sergay, SM ;

Sumner, AJ ;

Swenson, MR ;

Teitel, L .

ANNALS OF NEUROLOGY, 1996, 39 (02) :256-260

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