Berberine attenuates lipopolysaccharide-induced impairments of intestinal glutamine transport and glutaminase activity in rat

被引：15

作者：

Niu, Lingying ^{[1
,2
]}

Qiao, Wei ^{[2
,3
]}

Hu, Zhendong ^{[1
,2
]}

Li, Ning ^{[1
,2
]}

Huang, Qian ^{[1
]}

Gong, Jianfeng ^{[1
]}

Li, Qiurong ^{[1
,2
]}

Zhu, Weiming ^{[1
,2
]}

Li, Jieshou ^{[1
,2
]}

机构：

[1] Jinling Hosp, Res Inst Gen Surg, Nanjing 210002, Jiangsu, Peoples R China

[2] Najing Univ, Sch Med, Nanjing 210093, Jiangsu, Peoples R China

[3] Nanjing Univ, Affiliated Drum Tower Hosp, Coll Med, Dept Vasc Surg, Nanjing 210008, Jiangsu, Peoples R China

来源：

FITOTERAPIA | 2011年 / 82卷 / 03期

关键词：

Berberine; Intestine; Glutamine; B(0)AT1; Glutaminase; Lipopolysaccharide; GUT; METABOLISM; SEPSIS; INJURY; RNA; ENDOTOXEMIA; EXPRESSION; CELL;

D O I：

10.1016/j.fitote.2010.11.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Berberine was reported to protect against the intestinal injury and improve the survival rate in sepsis, and glutamine deficiency was considered to be correlated with mortality in sepsis. We found that berberine pretreatment ameliorated lipopolysaccharide-induced direct intestinal injury and mucosal hypoplasia and attenuated impairments of intestinal glutamine transport and glutaminase activity, B(0)AT1 mRNA and protein expressions, and glutaminase protein expression. These findings showed the first time that berberine pretreatment could improve intestinal recovery and attenuate the impairment of glutamine transport and glutaminase activity in rat sepsis. This might be one of the mechanisms for the beneficial effect of berberine on sepsis. (c) 2010 Elsevier B.V. All rights reserved.

引用

页码：323 / 330

页数：8

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