Diquafosol Ophthalmic Solution Increases Pre- and Postlens Tear Film During Contact Lens Wear in Rabbit Eyes

被引：11

作者：

Nagahara, Yukiko ^{[1
]}

Koh, Shizuka ^{[1
]}

Oshita, Yoshihiro ^{[2
]}

Nagano, Takashi ^{[2
]}

Mano, Hidetoshi ^{[2
]}

Nishida, Kohji ^{[1
]}

Watanabe, Hitoshi ^{[1
,3
]}

机构：

[1] Osaka Univ, Grad Sch Med, Dept Ophthalmol, Room E7,2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[2] Santen Pharmaceut Co Ltd, Nara Res & Dev Ctr, Ikoma, Nara, Japan

[3] Kansai Rosai Hosp, Dept Ophthalmol, Amagasaki, Hyogo, Japan

来源：

EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE | 2017年 / 43卷 / 06期

关键词：

Contact lenses; Diquafosol; Prelens tear film; Postlens tear film; TFOS INTERNATIONAL WORKSHOP; DRY-EYE; SODIUM HYALURONATE; DISCOMFORT REPORT; FLUID SECRETION; MENISCUS HEIGHT; THICKNESS; EFFICACY; DISEASE; SUBCOMMITTEE;

D O I：

10.1097/ICL.0000000000000283

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Objectives: To investigate the behavior of prelens tear film (PLTF) and postlens tear film (PoLTF) after the instillation of diquafosol using an experimental rabbit model of eyes with contact lens. Methods: Cross-sectional, anterior segment optical coherence tomographic images of the inferior midperipheral cornea were obtained at baseline and at 5, 15, 30, 60, 90, and 120 min after the instillation of 3% diquafosol ophthalmic solution in 10 Japanese white rabbits wearing contact lenses. From the obtained images, the areas of the PLTF and PoLTF were calculated. Both artificial tear solution and 0.1% sodium hyaluronate ophthalmic solution were used for comparison. Results: Significant fluid accumulation in both the PLTF and PoLTF was observed after diquafosol instillation, whereas no fluid accumulation was visible after the instillation of artificial tear or sodium hyaluronate. The increase in PLTF area after diquafosol instillation was significantly higher (P < 0.01) at 15 and 30 min than that after the instillation of artificial tear or sodium hyaluronate. The increase in PoLTF area up to 60 min after the instillation of diquafosol was significantly higher ( P < 0.01) than that after the instillation of either of the other two drugs. Conclusions: Instillation of 3% diquafosol ophthalmic solution increases PLTF and PoLTF in rabbit eyes with contact lenses. Diquafosol has potential as a treatment option for contact lens-related dry eye.

引用

页码：378 / 382

页数：5

共 41 条

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