Highly Oxygenated Guaianolides from Artemisia dubia

被引：30

作者：

Huang, Zheng-Sheng ^{[1
,3
]}

Pei, Yue-Hu ^{[3
]}

Liu, Chu-Mei ^{[1
]}

Lin, Sheng ^{[1
]}

Tang, Jian ^{[1
]}

Huang, Da-Sen ^{[1
,3
]}

Song, Tai-Fa ^{[1
]}

Lu, Long-Hai ^{[1
]}

Gao, Yan-Ping ^{[1
]}

Zhang, Wei-Dong ^{[1
,2
]}

机构：

[1] Second Mil Med Univ, Coll Pharm, Dept Phytochem, Shanghai 200433, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200030, Peoples R China

[3] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Liaoning Prov, Peoples R China

来源：

PLANTA MEDICA | 2010年 / 76卷 / 15期

关键词：

Artemisia dubia; Asteraceae; guaianolides; artemdubolides A-H; cytotoxic activities; sesquiterpene lactones; OCCURRING TERPENE DERIVATIVES; SESQUITERPENE LACTONES; GERMACRANOLIDES; LUDOVICIANA; COMPOSITAE; ARTECANIN; FAMILY;

D O I：

10.1055/s-0030-1249957

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Investigation of a Chinese folk medicine, Artemisia dubia (syn. Artemisia subdigitata), has resulted in the isolation of eight new guaianolides (artemdubolides A-H, 1-8), and nineteen known sesquiterpene lactones. Their structures were elucidated primarily on the basis of spectroscopic methods, including extensive 2D NMR experiments. The cytotoxic activities of compounds 1-8 were evaluated against A549 (human lung adenocarcinoma), Colo205 (human colon carcinoma), HepG2 (human hepatoma), and MDA-MB-435 (human melanoma) cell lines. Compounds 2 and 5 showed weak cell growth inhibition of Colo205 and MDA-MB-435 cells.

引用

页码：1710 / 1716

页数：7

共 36 条

[1] Microbial transformation of sesquiterpene lactones by the fungi Cunninghamella echinulata and Rhizopus oryzae [J].

Barrero, AF ;

Oltra, JE ;

Raslan, DS ;

Saúde, DA .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (05) :726-729

[2] SESQUITERPENE LACTONES OF SAGEBRUSH - STRUCTURE OF ARTECANIN [J].

BHADANE, NR ;

SHAFIZADEH, F .

PHYTOCHEMISTRY, 1975, 14 (12) :2651-2653

[3] NATURALLY-OCCURRING TERPENE DERIVATIVES .466. TYPES OF SESQUITERPENES FROM ARTEMISIA-FILIFOLIA [J].

BOHLMANN, F ;

ZDERO, C ;

JAKUPOVIC, J ;

GREGER, H .

PHYTOCHEMISTRY, 1983, 22 (02) :503-507

[4] NATURALLY OCCURRING TERPENE DERIVATIVES .138. NEW FURANOEREMOPHILANES AND OTHER SESQUITERPENES FROM SPECIES EURYOPS [J].

BOHLMANN, F ;

ZDERO, C .

PHYTOCHEMISTRY, 1978, 17 (07) :1135-1153

[5]

Fischer NH., 1979, PROGR CHEM ORGANIC N

[6] CONSTITUENTS OF COMPOSITAE .23. CHLOROHYSSOPIFOLIN-C, D, E AND VAHLENIN, 4 NEW SESQUITERPENE LACTONES FROM CENTAUREA-HYSSOPIFOLIA [J].

GONZALEZ, AG ;

BERMEJO, J ;

BRETON, JL ;

MASSANET, GM ;

TRIANA, J .

PHYTOCHEMISTRY, 1974, 13 (07) :1193-1197

[7] NEW GERMACRANOLIDES FROM ARTEMISIA-HERBA-ALBA X-RAY CRYSTAL-STRUCTURES OF 3-BETA,8-ALPHA-DIHYDROXY-6-BETA-H,7-ALPHA-H,11-BETA-H-GERMACRAN-4(14),9(10)-DIEN-6,12-OLIDE AND THE CORRESPONDING 3-OXO-OLIDE [J].

GORDON, MM ;

VANDERVEER, D ;

ZALKOW, LH .

JOURNAL OF NATURAL PRODUCTS, 1981, 44 (04) :432-440

[8] RE-EXAMINATION AND FURTHER DEVELOPMENT OF A PRECISE AND RAPID DYE METHOD FOR MEASURING CELL-GROWTH CELL KILL [J].

HANSEN, MB ;

NIELSEN, SE ;

BERG, K .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 119 (02) :203-210

[9] NOVANIN - GERMACRANOLIDE FROM ARTEMISIA-NOVA [J].

IRWIN, MA ;

GEISSMAN, TA .

PHYTOCHEMISTRY, 1973, 12 (04) :875-878

[10] RUPICOLIN-A AND RUPICOLIN-B, RUPIN-A AND RUPIN-B, AND CUMAMBRIN-B OXIDE FROM ARTEMISIA-TRIPARTITA SSP - RUPICOLA [J].

IRWIN, MA ;

GEISSMAN, TA .

PHYTOCHEMISTRY, 1973, 12 (04) :863-869

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