Polyhydroxyalkanoates as biomaterials

被引：53
作者：
Bhagyashri, S. [1 ]
Gadgil, Thorat [1 ]
Killi, Naresh [1 ]
Rathna, Gundloori V. N. [1 ]
机构：
[1] CSIR Natl Chem Lab, Polymer Sci & Engn Div, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India
来源：
MEDCHEMCOMM | 2017年 / 8卷 / 09期
关键词：
DRUG-DELIVERY SYSTEMS; IN-VITRO; BIOMEDICAL INVESTIGATIONS; POLY(ETHYLENE GLYCOL); POLY(ESTER URETHANE)S; MEDICAL APPLICATION; ANTIBIOTIC RELEASE; MOLECULAR-WEIGHT; PHA SCAFFOLDS; TISSUE;
D O I：
10.1039/c7md00252a
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Polyhydroxyalkanoates (PHAs) are biopolymers synthesized by bacteria under unbalanced growth conditions. These biopolymers are considered as potential biomaterials for future applications because they are biocompatible, biodegradable, and easy to produce and functionalize with strong mechanical strength. Currently, PHAs are being extensively innovated for biomedical applications due to their prerequisite properties. The wide range of biomedical applications includes drug delivery systems, implants, tissue engineering, scaffolds, artificial organ constructs, etc. In this article we review the utility of PHAs in various forms (bulk/nano) for biomedical applications so as to bring about the future vision for PHAs as biomaterials for the advancement of research and technology.
引用
收藏
页码：1774 / 1787
页数：14
相关论文
共 136 条
  • [1] Microbial synthesis of poly(β-hydroxyalkanoates) bearing phenyl groups from Pseudomonas putida:: Chemical structure and characterization
    Abraham, GA
    Gallardo, A
    Roman, JS
    Olivera, ER
    Jodra, R
    García, B
    Miñambres, B
    García, JL
    Luengo, JM
    [J]. BIOMACROMOLECULES, 2001, 2 (02) : 562 - 567
  • [2] Encapsulation and controlled release of L-leuprolide from poly(β-hydroxyalkanoate)s: impact of microstructure and chemical functionalities
    Ajellal, Noureddine
    Thomas, Christophe M.
    Aubry, Thierry
    Grohens, Yves
    Carpentier, Jean-Francois
    [J]. NEW JOURNAL OF CHEMISTRY, 2011, 35 (04) : 876 - 880
  • [3] Production of polyhydroxyalkanoates: the future green materials of choice
    Akaraonye, Everest
    Keshavarz, Tajalli
    Roy, Ipsita
    [J]. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 2010, 85 (06) : 732 - 743
  • [4] Preparation and Characterization of Polyhydroxyalkanoates Macroporous Scaffold Through Enzyme-Mediated Modifications
    Ansari, Nor Faezah
    Amirul, A. A.
    [J]. APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2013, 170 (03) : 690 - 709
  • [5] A micellization study of medium chain length poly(3-hydroxyalkanoate)-based amphiphilic diblock copolymers
    Babinot, Julien
    Guigner, Jean-Michel
    Renard, Estelle
    Langlois, Valerie
    [J]. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2012, 375 : 88 - 93
  • [6] Exopolysaccharide of the gellan family: prospects and potential
    Banik, RM
    Kanari, B
    Upadhyay, SN
    [J]. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2000, 16 (05) : 407 - 414
  • [7] New Linear and Star-Shaped Thermogelling Poly([R]-3-hydroxybutyrate) Copolymers
    Barouti, Ghislaine
    Liow, Sing Shy
    Dou, Qingqing
    Ye, Hongye
    Orione, Clement
    Guillaume, Sophie M.
    Loh, Xian Jun
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (30) : 10501 - 10512
  • [8] Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications
    Berger, J
    Reist, M
    Mayer, JM
    Felt, O
    Peppas, NA
    Gurny, R
    [J]. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 2004, 57 (01) : 19 - 34
  • [9] Polyhydroxyalkanoates as Potential Biomaterials for Neural Tissue Regeneration
    Biazar, Esmaeil
    [J]. INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, 2014, 63 (17) : 898 - 908
  • [10] A nanofibrous PHBV tube with Schwann cell as artificial nerve graft contributing to Rat sciatic nerve regeneration across a 30-mm defect bridge
    Biazar, Esmaeil
    Keshel, Saeed Heidari
    [J]. CELL COMMUNICATION AND ADHESION, 2013, 20 (1-2) : 41 - 49
12345678910