Novel antimicrobial agents for combating antibiotic-resistant bacteria

被引:127
作者
Chang, Rachel Yoon Kyung [1 ]
Nang, Sue C. [2 ,3 ]
Chan, Hak-Kim [1 ]
Li, Jian [2 ,3 ]
机构
[1] Univ Sydney, Fac Med & Hlth, Sydney Pharm Sch, Adv Drug Delivery Grp, Sydney, NSW, Australia
[2] Monash Univ, Biomed Discovery Inst, Clayton, Vic, Australia
[3] Monash Univ, Dept Microbiol, Clayton, Vic, Australia
基金
澳大利亚国家健康与医学研究理事会;
关键词
Antimicrobial resistance; ESKAPE; Bacteriophage (phage); Endolysin; Immunomodulators; Monoclonal antibodies; PSEUDOMONAS-AERUGINOSA; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; ACINETOBACTER-BAUMANNII; PHAGE THERAPY; STREPTOCOCCUS-PNEUMONIAE; INFECTION; BACTERIOPHAGES; LYSIN; BIOFILM;
D O I
10.1016/j.addr.2022.114378
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Antibiotic therapy has become increasingly ineffective against bacterial infections due to the rise of resistance. In particular, ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) have caused life threatening infections in humans and represent a major global health threat due to a high degree of antibiotic resistance. To respond to this urgent call, novel strategies are urgently needed, such as bacteriophages (or phages), phage-encoded enzymes, immunomodulators and monoclonal antibodies. This review critically analyses these promising antimicrobial therapies for the treatment of multidrugresistant bacterial infections. Recent advances in these novel therapeutic strategies are discussed, focusing on preclinical and clinical investigations, as well as combinatorial approaches. In this 'Bad Bugs, No Drugs' era, novel therapeutic strategies can play a key role in treating deadly infections and help extend the lifetime of antibiotics.(c) 2022 Elsevier B.V. All rights reserved.
引用
收藏
页数:23
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