Intracisternal injection of palmitoylethanolamide inhibits the peripheral nociceptive evoked responses of dorsal horn wide dynamic range neurons

被引：8
作者：
Gonzalez-Hernandez, Abimael [1 ]
Martinez-Lorenzana, Guadalupe [1 ]
Rodriguez-Jimenez, Javier [1 ]
Rojas-Piloni, Gerardo [1 ]
Condes-Lara, Miguel [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Inst Neurobiol, Dept Neurobiol Desarrollo & Neurofisiol, Queretaro 76230, Mexico
来源：
JOURNAL OF NEURAL TRANSMISSION | 2015年 / 122卷 / 03期
关键词：
5-HT receptors; Analgesia; Descending analgesic mechanisms; Endocannabinoids; Pain; ACTIVATED-RECEPTOR-ALPHA; SPINAL-CORD-INJURY; PAIN; PATHWAYS; MODULATION; ANANDAMIDE; OXYTOCIN; AGONIST; RATS; MICE;
D O I：
10.1007/s00702-014-1255-6
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Endogenous palmitoylethanolamide (PEA) has a key role in pain modulation. Central or peripheral PEA can reduce nociceptive behavior, but no study has yet reported a descending inhibitory effect on the neuronal nociceptive activity of Ad-and C-fibers. This study shows that intracisternal PEA inhibits the peripheral nociceptive responses of dorsal horn wide dynamic range cells (i.e., inhibition of Ad-and C-fibers), an effect blocked by spinal methiothepin. These results suggest that a descending analgesic mechanism mediated by the serotonergic system could be activated by central PEA.
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收藏
页码：369 / 374
页数：6
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