Clinical characteristics associated with non-small-cell lung cancer harboring ALK rearrangements in Chinese patients

被引：9

作者：

Tian, Guangming ^{[1
]}

Zhao, Xinliang ^{[2
]}

Nie, Jun ^{[1
]}

Dai, Ling ^{[1
]}

Hu, Weiheng ^{[1
]}

Zhang, Jie ^{[1
]}

Chen, Xiaoling ^{[1
]}

Han, Jindi ^{[1
]}

Ma, Xiangjuan ^{[1
]}

Wu, Di ^{[1
]}

Han, Sen ^{[1
]}

Long, Jieran ^{[1
]}

Wang, Yang ^{[1
]}

Fang, Jian ^{[1
]}

机构：

[1] Peking Univ Canc Hosp & Inst, Dept Thorac Oncol 2, Beijing, Peoples R China

[2] Peking Univ, Dept Med Genet, Hlth Sci Ctr, Beijing 100871, Peoples R China

来源：

FUTURE ONCOLOGY | 2016年 / 12卷 / 10期

关键词：

adenocarcinoma; ALK rearrangements; gene mutations; non-small-cell lung cancer; EML4-ALK FUSION GENE; CLINICORADIOLOGIC CHARACTERISTICS; KRAS MUTATIONS; EGFR; ADENOCARCINOMAS; CHEMOTHERAPY; CRIZOTINIB; FEATURES; IDENTIFICATION; STATISTICS;

D O I：

10.2217/fon.15.361

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: The ALK inhibitor, crizotinib, has demonstrated effectiveness in patients with non-small-cell lung cancer harboring ALK rearrangements. As few studies of the clinical characteristics of Chinese patients with ALK rearrangements have been reported, we conduct this study to gain more understanding in such area among Chinese patients. Patients & methods: We undertook a retrospective study of 288 non-small-cell lung cancer patients admitted to our institution over a period of 4.5 years. Results: Following testing, 14.9% of the patients (43/288) were found to be ALK fusion gene positive. Patient data including gender, age, smoking status, EGFR mutation status and medical imaging data were collected and analyzed. Conclusion: The findings suggested that patients with ALK rearrangements are more likely to be young, have EGFR wild-type, and more likely to exhibit mucus secretion, solid tumor growth, lymph node metastasis and pleural metastasis.

引用

页码：1243 / 1249

页数：7

共 32 条

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