Cross-correlation of instantaneous amplitudes of field potential oscillations: A straightforward method to estimate the directionality and lag between brain areas

被引:86
作者
Adhikari, Avishek [2 ]
Sigurdsson, Torfi [1 ]
Topiwala, Mihir A. [1 ]
Gordon, Joshua A. [1 ,3 ]
机构
[1] Columbia Univ, Dept Psychiat, New York, NY 10032 USA
[2] Columbia Univ, Dept Biol Sci, New York, NY 10032 USA
[3] New York State Psychiat Inst & Hosp, Div Integrat Neurosci, New York, NY 10032 USA
关键词
Cross-correlation; Theta oscillations; Medial prefrontal cortex; Ventral hippocampus; Local field potential; Functional connectivity; Partial directed coherence; PARTIAL DIRECTED COHERENCE; MEDIAL PREFRONTAL CORTEX; CAT STRIATE CORTEX; FUNCTIONAL CONNECTIVITY; THETA-OSCILLATIONS; HIPPOCAMPUS; PROJECTIONS; SYNCHRONY; FREQUENCY; RHYTHMS;
D O I
10.1016/j.jneumeth.2010.06.019
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Researchers performing multi-site recordings are often interested in identifying the directionality of functional connectivity and estimating lags between sites. Current techniques for determining directionality require spike trains or involve multivariate autoregressive modeling. However, it is often difficult to sample large numbers of spikes from multiple areas simultaneously, and modeling can be sensitive to noise. A simple, model-independent method to estimate directionality and lag using local field potentials (LFPs) would be of general interest. Here we describe such a method using the cross-correlation of the instantaneous amplitudes of filtered LFPs. The method involves four steps. First, LFPs are band-pass filtered; second, the instantaneous amplitude of the filtered signals is calculated; third, these amplitudes are cross-correlated and the lag at which the cross-correlation peak occurs is determined: fourth, the distribution of lags obtained is tested to determine if it differs from zero. This method was applied to LFPs recorded from the ventral hippocampus and the medial prefrontal cortex in awake behaving mice. The results demonstrate that the hippocampus leads the mPFC, in good agreement with the time lag calculated from the phase locking of mPFC spikes to vHPC LFP oscillations in the same dataset. We also compare the amplitude cross-correlation method to partial directed coherence, a commonly used multivariate autoregressive model-dependent method, and find that the former is more robust to the effects of noise. These data suggest that the cross-correlation of instantaneous amplitude of filtered LFPs is a valid method to study the direction of flow of information across brain areas. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:191 / 200
页数:10
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