Plasma Heme Oxygenase-1 Concentration Is Elevated in Individuals with Type 2 Diabetes Mellitus

被引:90
作者
Bao, Wei [1 ,2 ]
Song, Fangfang [1 ,2 ,3 ]
Li, Xiangyang [1 ,2 ]
Rong, Shuang [1 ,2 ]
Yang, Wei [1 ,2 ]
Zhang, Muxun [4 ]
Yao, Ping [1 ,2 ]
Hao, Liping [1 ,2 ]
Yang, Nianhong [1 ,2 ]
Hu, Frank B. [5 ,6 ,7 ,8 ]
Liu, Liegang [1 ,2 ]
机构
[1] Huazhong Univ Sci & Technol, Dept Food Hyg & Nutr, Tongji Med Coll, Sch Publ Hlth, Wuhan 430074, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Key Lab Environm & Hlth, Wuhan 430074, Peoples R China
[3] Tianjin Med Univ, Canc Inst & Hosp, Dept Epidemiol & Biostat, Tianjin, Peoples R China
[4] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Internal Med,Inst Endocrinol, Wuhan 430074, Peoples R China
[5] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[6] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[7] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA USA
[8] Harvard Univ, Sch Med, Boston, MA USA
关键词
ACTIVATED SIGNALING PATHWAYS; BETA-CELL DYSFUNCTION; OXIDATIVE STRESS; INSULIN-RESISTANCE; GENE-EXPRESSION; GLUCOSE; DEFENSE; DIAGNOSIS; P22(PHOX); DISEASE;
D O I
10.1371/journal.pone.0012371
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). Methods and Findings: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P < 0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P < 0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55-12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMAIR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. Conclusions: Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications.
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页数:7
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