IL-21 and IL-21 receptor - A new cytokine pathway modulates innate and adaptive immunity

被引：44
|
作者：
Collins, M [1 ]
Whitters, MJ [1 ]
Young, DA [1 ]
机构：
[1] Wyeth Res, Immunol RA, Musculoskeletal Sci, Inflammat, Cambridge, MA 02140 USA
来源：
IMMUNOLOGIC RESEARCH | 2003年 / 28卷 / 02期
关键词：
IL-21; IL-21R; IL-21R-deficient mice; gamma-common; NK cell; T cell; B cell; cytokine;
D O I：
10.1385/IR:28:2:131
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Interleukin (IL)-21 is a new member of the type I cytokine superfamily. Although it is most homologous to IL-15, it has a unique receptor chain, IL-21R,that pairs with the gamma-common cytokine receptor chain. The first experiments examining the biology of the IL-21 pathway reveal that it is a cytokine with effects on natural killer (NK) cells, T cells, and B cells. Mice deficient in the IL-21R have also been made, and are being examined for the effects of the IL-21/IL-21R pathway in vivo. Here we summarize our current knowledge of this new cytokine pathway, and its role in innate and adaptive immunity.
引用
收藏
页码：131 / 140
页数：10
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