The igf-1 receptor in cancer biology

被引：515
作者：
Baserga, R
Peruzzi, F
Reiss, K
机构：
[1] Thomas Jefferson Univ, Kimmel Canc Ctr, Philadelphia, PA 19107 USA
[2] Temple Univ, Ctr Neurovirol & Canc Biol, Philadelphia, PA 19122 USA
来源：
INTERNATIONAL JOURNAL OF CANCER | 2003年 / 107卷 / 06期
关键词：
IGF-1; receptor; cell growth; cell proliferation; apoptosis;
D O I：
10.1002/ijc.11487
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The type I insulin-like growth factor receptor (IGF-IR) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-IR leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码：873 / 877
页数：5
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