Biomimetic Total Synthesis of Meiogynin A, an Inhibitor of Bcl-xL, and Bak Interaction

被引：20

作者：

Fotsop, Dalia Fomekong ^{[1
]}

Roussi, Fanny ^{[1
]}

Leverrier, Aurelie ^{[1
]}

Breteche, Anne ^{[1
]}

Gueritte, Francoise ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, UPR 2301, F-91198 Gif Sur Yvette, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 21期

关键词：

REVISED STRUCTURE; CARBOMETALATION; ALKYNES;

D O I：

10.1021/jo101088h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short, convergent, and selective synthesis of meiogynin A, an inhibitor of the antiapoptotic protein Bcl-xL, has been performed. This synthesis, based on a biomimetic approach, allowed the determination of its absolute configuration. Three isomers of meiogynin A have also been elaborated. One of these was found to be three times more potent than the natural compound.

引用

页码：7412 / 7415

页数：4

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