Increased serum acetylcholine receptor α1 subunit protein in anti-acetylcholine receptor antibody-positive myasthenia gravis

被引：3

作者：

Uzawa, Akiyuki ^{[1
]}

Ozawa, Yukiko ^{[1
]}

Yasuda, Manato ^{[1
]}

Oda, Fumiko ^{[1
]}

Kojima, Yuta ^{[1
,2
]}

Kawaguchi, Naoki ^{[1
,3
]}

Kanai, Tetsuya ^{[1
]}

Himuro, Keiichi ^{[1
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Neurol, Chiba, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Neurol, Kyoto, Japan

[3] Neurol Chiba Clin, Dept Neurol, Chiba, Japan

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2020年 / 339卷

关键词：

Anti-acetylcholine receptor antibody; Neuromuscular junction damage; Biomarker; Myasthenia gravis;

D O I：

10.1016/j.jneuroim.2019.577125

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Complement-dependent disruption of motor endplate is detected in anti-acetylcholine receptor (AChR) antibody-positive myasthenia gravis (MG). We measured serum AChR alpha 1 subunit protein levels, which may be associated with neuromuscular damage, in 55 patients with MG (47 were seropositive and 8 were negative) and in 20 controls. Serum AChR alpha 1 subunit protein concentrations were higher in patients with anti-AChR antibody-positive MG than those in controls (P = .04), were negatively correlated with MG activities of daily living score (P = .01), and tended to be higher in ocular MG than in generalized MG. AChR alpha 1 subunit protein elevation may be related to seropositive MG pathogenesis, especially in the ocular type.

引用

页数：3

共 7 条

[1] Myasthenia gravis - Recommendations for clinical research standards [J].