Ultra-rapid synthesis of 15O-labeled 2-deoxy-D-glucose for positron emission tomography (PET)

被引：20
作者：
Yorimitsu, H
Murakami, Y
Takamatsu, H
Nishimura, S
Nakamura, E [1 ]
机构：
[1] Univ Tokyo, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan
[2] Fujisawa Pharmaceut Co Ltd, Adv Technol Platform Res Lab, Tsukuba, Ibaraki 3002698, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 18期
关键词：
hydroxylation; imaging agents; isotopic labeling; radical reactions; radiopharmaceuticals;
D O I：
10.1002/anie.200500044
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Make it quick! The oxygen isotope 15O has a half-life of only 2 min, and was incorporated into a sugar through an ultrarapid radical hydroxylation of 2,6-dideoxy-6-iodo-D-glucose with labeled molecular oxygen to provide 6-[15O]-2-deoxy-D-glucose (see scheme). The product accumulates in metabolically active organs of rats similarly to a 18F-based tracer in common use, and represents a promising alternative for medical imaging. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2708 / 2711
页数：4
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