Pregabalin-induced generalized myoclonic status epilepticus in patients with chronic pain

被引:19
作者
Knake, S. [1 ]
Klein, K. M. [1 ]
Hattemer, K. [1 ]
Wellek, A. [1 ]
Oertel, W. H. [1 ]
Hamer, H. M. [1 ]
Rosenow, F. [1 ]
机构
[1] Univ Marburg, Dept Neurol, D-35033 Marburg, Germany
关键词
pregabalin; status epilepticus; myoclonus; pain;
D O I
10.1016/j.yebeh.2007.06.012
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Pregabalin is often used for the treatment of chronic pain syndromes. We here describe two patients with chronic pain and pregabalin-induced myoclonic status epilepticus. Patients treated with pregabalin who experience sudden behavioral changes or mycloni should be investigated for this possible side effect, and pregabalin should be reduced or discontinued if myocloni or status epilepticus occurs. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:471 / 473
页数:3
相关论文
共 7 条
[1]   Myoclonus in epilepsy patients with anticonvulsive add-on therapy with pregabalin [J].
Huppertz, HJ ;
Feuerstein, TJ ;
Schulze-Bonhage, A .
EPILEPSIA, 2001, 42 (06) :790-792
[2]   Tiagabine-induced absence status in idiopathic generalized epilepsy [J].
Knake, S ;
Hamer, HM ;
Schomburg, U ;
Oertel, WH ;
Rosenow, F .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 1999, 8 (05) :314-317
[3]   MYOCLONUS [J].
SHIBASAKI, H .
CURRENT OPINION IN NEUROLOGY, 1995, 8 (04) :331-334
[4]   Pregabalin:: A novel γ-aminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders [J].
Tassone, Daniel M. ;
Boyce, Eric ;
Guyer, Jennifer ;
Nuzum, Donald .
CLINICAL THERAPEUTICS, 2007, 29 (01) :26-48
[5]   Pharmacology and mechanism of action of pregabalin:: The calcium channel α2-δ (alpha2-delta) subunit as a target for antiepileptic drug discovery [J].
Taylor, Charles P. ;
Angelotti, Timothy ;
Fauman, Eric .
EPILEPSY RESEARCH, 2007, 73 (02) :137-150
[6]   Absence and myoclonic status epilepticus precipitated by antiepileptic drugs in idiopathic generalized epilepsy [J].
Thomas, P ;
Valton, L ;
Genton, P .
BRAIN, 2006, 129 :1281-1292
[7]   Activity profile of pregabalin in rodent models of epilepsy and ataxia [J].
Vartanian, MG ;
Radulovic, LL ;
Kinsora, JJ ;
Serpa, KA ;
Vergnes, M ;
Bertram, E ;
Taylor, CP .
EPILEPSY RESEARCH, 2006, 68 (03) :189-205