New environmentally-friendly solvent-free synthesis of imines using calcium oxide under microwave irradiation

被引：51

作者：

Gopalakrishnan, M. ^{[1
]}

Sureshkumar, P. ^{[1
]}

Kanagarajan, V. ^{[1
]}

Thanusu, J. ^{[1
]}

机构：

[1] Annamalai Univ, Dept Chem, Annamalainagar 608002, Tamil Nadu, India

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2007年 / 33卷 / 06期

关键词：

calcium oxide; imines; solvent-free conditions; microwave irradiation; green chemistry;

D O I：

10.1163/156856707782565822

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Condensation of structurally diverse aldehydes including heterocyclic aldehydes, like furfural, with various amines in the presence of calcium oxide affording the corresponding imines in solvent-free conditions in good to excellent yields under microwave irradiation is described. A comparative study has been done under thermal conditions. The synergy between dry media and microwave irradiation in this reaction is evaluated by condensing less electrophilic aldehydes with poorly nucleophilic amines. The main advantages of this environmentally friendly protocol are the use of the non-toxic and inexpensive reagent calcium oxide and the considerable rate enhancement in comparison with a thermal reaction.

引用

页码：541 / 548

页数：8

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