A Review of Systemic Minocycline Side Effects and Topical Minocycline as a Safer Alternative for Treating Acne and Rosacea

被引:57
作者
Martins, Ana M. [1 ]
Marto, Joana M. [1 ]
Johnson, Jodi L. [2 ]
Graber, Emmy M. [3 ,4 ]
机构
[1] Univ Lisbon, Res Inst Med iMed ULisboa, Fac Pharm, P-1649003 Lisbon, Portugal
[2] Northwestern Univ, Feinberg Sch Med, Dept Pathol & Dermatol, Chicago, IL 60611 USA
[3] Dermatol Inst, Boston, MA 02116 USA
[4] Northeastern Univ, Boston, MA 02115 USA
来源
ANTIBIOTICS-BASEL | 2021年 / 10卷 / 07期
关键词
minocycline; tetracycline; acne vulgaris; rosacea; ACUTE EOSINOPHILIC PNEUMONIA; SYMPTOMS DRESS SYNDROME; DRUG REACTION; HYPERSENSITIVITY SYNDROME; INDUCED HYPERPIGMENTATION; CYTOPLASMIC ANTIBODY; PSEUDOTUMOR CEREBRI; DOSE DOXYCYCLINE; SERUM SICKNESS; INDUCED LUPUS;
D O I
10.3390/antibiotics10070757
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Resistance of Cutibacterium acnes to topical antibiotics historically used to treat acne (topical erythromycin and clindamycin and, more recently, topical azithromycin and clarithromycin) has been steadily increasing and new topical antibiotics are needed. Minocycline is a semisynthetic tetracycline-derived antibiotic currently used systemically to treat a wide range of infections caused by Gram-negative and Gram-positive bacteria. In addition to its antibiotic activity, minocycline possesses anti-inflammatory properties, such as the downregulation of proinflammatory cytokine production, suppression of neutrophil chemotaxis, activation of superoxide dismutase, and inhibition of phagocytosis, among others. These characteristics make minocycline a valuable agent for treatment of dermatological diseases such as acne vulgaris and papulopustular rosacea. However, more frequent or serious adverse effects have been observed upon the systemic administration of minocycline than with other tetracyclines. Examples of serious adverse effects include hypersensitivity syndrome reaction, drug-induced lupus, idiopathic intracranial hypertension, and other autoimmune syndromes that may cause death. Here, we review adverse effects and drug-drug interactions observed with oral administration of minocycline and contrast this with topical minocycline formulations recently approved or under development for effectively treating dermatological disorders with fewer adverse effects and less drug interaction.
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页数:23
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