BioMoby web services to support clustering of co-regulated genes based on similarity of promoter configurations

被引:11
作者
Kerhornou, Arnaud [1 ]
Guigo, Roderic
机构
[1] Inst Municipal Invest Med, Ctr Regulacio Genom, E-08003 Barcelona, Catalonia, Spain
[2] Inst Municipal Invest Med, Res Grp Biomed Informat, E-08003 Barcelona, Catalonia, Spain
[3] Univ Pompeu Fabra, E-08003 Barcelona, Catalonia, Spain
[4] Wellcome Trust Genome Campus, EBI, Cambridge CB10 1SD, England
关键词
D O I
10.1093/bioinformatics/btm252
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Here we present a computational protocol to analyze the promoter regions of a given set of co-expressed genes, and its implementation through the use of Web services technologies. This protocol aims to cluster a set of co-regulated genes in subsets of genes showing similar configurations of transcription factor binding sites. All the steps of this protocol have been developed as web services that are compliant with BioMoby specifications.
引用
收藏
页码:1831 / 1833
页数:3
相关论文
共 13 条
[1]   gff2ps:: visualizing genomic annotations [J].
Abril, JF ;
Guigó, R .
BIOINFORMATICS, 2000, 16 (08) :743-744
[2]   Ensembl 2006 [J].
Birney, E. ;
Andrews, D. ;
Caccamo, M. ;
Chen, Y. ;
Clarke, L. ;
Coates, G. ;
Cox, T. ;
Cunningham, F. ;
Curwen, V. ;
Cutts, T. ;
Down, T. ;
Durbin, R. ;
Fernandez-Suarez, X. M. ;
Flicek, P. ;
Graf, S. ;
Hammond, M. ;
Herrero, J. ;
Howe, K. ;
Iyer, V. ;
Jekosch, K. ;
Kahari, A. ;
Kasprzyk, A. ;
Keefe, D. ;
Kokocinski, F. ;
Kulesha, E. ;
London, D. ;
Longden, I. ;
Melsopp, C. ;
Meidl, P. ;
Overduin, B. ;
Parker, A. ;
Proctor, G. ;
Prlic, A. ;
Rae, M. ;
Rios, D. ;
Redmond, S. ;
Schuster, M. ;
Sealy, I. ;
Searle, S. ;
Severin, J. ;
Slater, G. ;
Smedley, D. ;
Smith, J. ;
Stabenau, A. ;
Stalker, J. ;
Trevanion, S. ;
Ureta-Vidal, A. ;
Vogel, J. ;
White, S. ;
Woodwark, C. .
NUCLEIC ACIDS RESEARCH, 2006, 34 :D556-D561
[3]   Multiple non-collinear TF-map alignments of promoter regions [J].
Blanco, Enrique ;
Guigo, Roderic ;
Messeguer, Xavier .
BMC BIOINFORMATICS, 2007, 8 (1)
[4]   Transcription factor map alignment of promoter regions [J].
Blanco, Enrique ;
Messeguer, Xavier ;
Smith, Temple F. ;
Guigo, Roderic .
PLOS COMPUTATIONAL BIOLOGY, 2006, 2 (05) :403-416
[5]   A hierarchical unsupervised growing neural network for clustering gene expression patterns [J].
Herrero, J ;
Valencia, A ;
Dopazo, J .
BIOINFORMATICS, 2001, 17 (02) :126-136
[6]   Taverna: a tool for building and running workflows of services [J].
Hull, Duncan ;
Wolstencroft, Katy ;
Stevens, Robert ;
Goble, Carole ;
Pocock, Mathew R. ;
Li, Peter ;
Oinn, Tom .
NUCLEIC ACIDS RESEARCH, 2006, 34 :W729-W732
[7]   BioMoby extensions to the Taverna workflow management and enactment software [J].
Kawas, Edward ;
Senger, Martin ;
Wilkinson, Mark D. .
BMC BIOINFORMATICS, 2006, 7 (1)
[8]   TRANSFAC® and its module TRANSCompel®:: transcriptional gene regulation in eukaryotes [J].
Matys, V. ;
Kel-Margoulis, O. V. ;
Fricke, E. ;
Liebich, I. ;
Land, S. ;
Barre-Dirrie, A. ;
Reuter, I. ;
Chekmenev, D. ;
Krull, M. ;
Hornischer, K. ;
Voss, N. ;
Stegmaier, P. ;
Lewicki-Potapov, B. ;
Saxel, H. ;
Kel, A. E. ;
Wingender, E. .
NUCLEIC ACIDS RESEARCH, 2006, 34 :D108-D110
[9]   Exploring Williams-Beuren syndrome using myGrid [J].
Stevens, R. D. ;
Tipney, H. J. ;
Wroe, C. J. ;
Oinn, T. M. ;
Senger, M. ;
Lord, P. W. ;
Goble, C. A. ;
Brass, A. ;
Tassabehji, M. .
BIOINFORMATICS, 2004, 20 :303-310
[10]   Identification and confirmation of a module of coexpressed genes [J].
Thompson, HGR ;
Harris, JW ;
Wold, BJ ;
Quake, SR ;
Brody, JP .
GENOME RESEARCH, 2002, 12 (10) :1517-1522