Representation of Minorities and Elderly Patients in Multiple Myeloma Clinical Trials

被引：42

作者：

Duma, Narjust ^{[1
]}

Azam, Tariq ^{[2
]}

Riaz, Irbaz Bin ^{[1
]}

Gonzalez-Velez, Miguel ^{[3
]}

Ailawadhi, Sikander ^{[4
]}

Go, Ronald ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Rochester, MN USA

[2] Mayo Clin, Dept Internal Med, Rochester, MN USA

[3] Rutgers State Univ, Internal Med, New Jersey Med Sch, Newark, NJ USA

[4] Mayo Clin, Hematol, Jacksonville, FL 32224 USA

来源：

ONCOLOGIST | 2018年 / 23卷 / 09期

关键词：

Hematologic malignancies; Multiple myeloma; Clinical trials; Minorities; Elderly; DISPARITIES; ENROLLMENT; RACE; AGE;

D O I：

10.1634/theoncologist.2017-0592

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Multiple myeloma (MM) occurs in all races, but the incidence in non-Hispanic black patients (NHBs) is two to three times higher than in non-Hispanic white patients (NHWs). We determined the representation of minorities and elderly patients in MM clinical trials. Enrollment data from all therapeutic trials reported in from 2000 to 2016 were analyzed. Enrollment fraction (EF) was defined as the number of trial enrollees divided by the 2014 MM prevalence. Participation in MM clinical trials varied significantly across racial and ethnic groups; NHWs were more likely to be enrolled in clinical trials (EF 0.18%) than NHBs (EF 0.06%, p<.0001) and Hispanic patients (EF 0.04%, p<.0001). The median age of trial participants was 62 years, with 7,956 participants (66%) being less than 65 years of age. Collaborations between investigators, sponsors, and the community are necessary to increase access to clinical trials to our minority and elderly patients.

引用

页码：1076 / 1078

页数：3

共 10 条

[1] Outcome disparities in multiple myeloma: a SEER-based comparative analysis of ethnic subgroups [J].