Social determinants and lifestyle factors for brain health: implications for risk reduction of cognitive decline and dementia

被引:43
作者
Roehr, Susanne [1 ,2 ]
Pabst, Alexander [1 ]
Baber, Ronny [3 ,4 ]
Engel, Christoph [4 ,5 ]
Glaesmer, Heide [6 ]
Hinz, Andreas [6 ]
Schroeter, Matthias L. [7 ,8 ]
Witte, A. Veronica [7 ]
Zeynalova, Samira [4 ,5 ]
Villringer, Arno [7 ,8 ]
Loeffler, Markus [4 ,5 ]
Riedel-Heller, Steffi G. [1 ]
机构
[1] Univ Leipzig, Med Fac, Inst Social Med Occupat Hlth & Publ Hlth ISAP, Philipp Rosenthal Str 55, D-04103 Leipzig, Germany
[2] Trinity Coll Dublin, Global Brain Hlth Inst GBHI, Dublin, Ireland
[3] Univ Hosp Leipzig, Inst Lab Med Clin Chem & Mol Diagnost, Leipzig, Germany
[4] Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany
[5] Univ Leipzig, Inst Med Informat Stat & Epidemiol IMISE, Leipzig, Germany
[6] Univ Leipzig, Dept Med Psychol & Med Sociol, Leipzig, Germany
[7] Max Planck Inst Human Cognit & Brain Sci, Leipzig, Germany
[8] Univ Hosp Leipzig, Clin Cognit Neurol, Leipzig, Germany
关键词
INTERVENTION; EDUCATION; IMPAIRMENT; PREVENTION; PROMOTION; DISEASE; FINGER; DESIGN;
D O I
10.1038/s41598-022-16771-6
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Substantial evidence indicates a huge potential for risk reduction of cognitive decline and dementia based on modifiable health and lifestyle factors. To maximize the chances for risk reduction, it is useful to investigate associations of social determinants and lifestyle for brain health. We computed the "LIfestyle for BRAin health" (LIBRA) score for baseline participants of the Leipzig Research Centre for Civilization Diseases (LIFE) Adult Study, a population-based urban cohort in Germany. LIBRA predicts dementia in midlife and early late life populations, comprising 12 modifiable risk factors (heart disease, kidney disease, diabetes, obesity, hypertension, hypercholesterolemia, alcohol consumption, smoking, physical inactivity, diet, depression, cognitive inactivity). Associations of social determinants (living situation, marital status, social isolation, education, net equivalence income, occupational status, socioeconomic status/SES, employment) with LIBRA were inspected using age- and sex-adjusted multivariable linear regression analysis. Z-standardization and sampling weights were applied. Participants (n = 6203) were M = 57.4 (SD = 10.6, range 40-79) years old and without dementia, 53.0% were women. Except for marital status, all considered social determinants were significantly associated with LIBRA. Beta coefficients for the association with higher LIBRA scores were most pronounced for low SES (beta = 0.80, 95% CI [0.72-0.88]; p < 0.001) and middle SES (beta = 0.55, 95% CI [0.47-0.62]; p < 0.001). Social determinants, particularly socioeconomic factors, are associated with lifestyle for brain health, and should thus be addressed in risk reduction strategies for cognitive decline and dementia. A social-ecological public health perspective on risk reduction might be more effective and equitable than focusing on individual lifestyle behaviors alone.
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页数:9
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