Bioactive humulene derivatives from Asteriscus vogelii

被引：31
作者：
Rauter, AP
Branco, J
Bermejo, J
González, AG
García-Grávalos, MD
Feliciano, AS
机构：
[1] Univ Lisbon, Fac Ciencias, Dept Quim & Bioquim, P-1749016 Lisbon, Portugal
[2] CSIC, IPNAC, Ctr Prod Nat Organ Antonio Gonzalez, Tenerife, Spain
[3] PharmaMar SA, Madrid, Spain
[4] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37008 Salamanca, Spain
来源：
PHYTOCHEMISTRY | 2001年 / 56卷 / 02期
关键词：
Asteriscus vogelii; compositae; humulenes; phytotoxicity; cytotoxicity;
D O I：
10.1016/S0031-9422(00)00304-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The bioactive fractions obtained from the extract of Asteriscus vagelii afforded a new humulene derivative, the 8-oxo-6,7,9,10-tetrahydrohumulen-1,12-olide (1), in addition to the known asteriscunolides A (2), C (3) and D (4), and the acids 8-oxo-alpha -humula-6Z,9Z-dien-12-oic acid (5), 8-oxo-alpha -humula-6E,9Z-dien-12-oic acid (6) and 8-oxo-alpha -humula-6E,9E-dien-12-oic acid (7), characterized as their methyl esters. Evaluation of their phytotoxic and cytotoxic activities was accomplished. Compounds 3 and 4 gave the highest inhibition of plant cell cultures and of the plant Lemna paucicostata. Compound 4 was also the most active against P-338 lymphoma in mice, A-549 carcinoma of human lung, HT-29 carcinoma of human colon and MEL-28 human melanoma. (C) 2001 Elsevier Science Ltd. All rights reserved.
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页码：167 / 171
页数：5
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