Localization Of poly-L-lysine - photo sensitizer conjugate in nucleus

被引：24

作者：

Ogura, S ^{[1
]}

Yazaki, K ^{[1
]}

Yamaguchi, K ^{[1
]}

Kamachi, T ^{[1
]}

Okura, I ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Bioengn, Midori Ku, Yokohama, Kanagawa 2268501, Japan

来源：

JOURNAL OF CONTROLLED RELEASE | 2005年 / 103卷 / 01期

关键词：

photodynamic therapy; chlorin e6; nuclear targeting; poly-L-lysine;

D O I：

10.1016/j.jconrel.2004.11.010

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The cellular uptake and photocytotoxity of poly-L-lysine (pL)-chlorin e6 (Ce6) conjugate were investigated. The cellular uptake of pL-Ce6 conjugate for HeLa cells was much higher than that of Ce6, and pL-Ce6 conjugate had high binding affinity for HeLa cells. pL-Ce6 conjugate was accumulated in the nucleus of HeLa cells, and the effective photocytotoxity was observed by the irradiation.

引用

页码：1 / 6

页数：6

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