Creutzfeldt-Jakob disease. Report of one case

被引：0

作者：

Ramirez, Marcos ^{[1
,3
]}

Gallardo, Andres ^{[1
]}

Vidal, Aaron ^{[3
]}

Cornejo, Sebastian ^{[4
]}

Ramirez, Dario ^{[2
]}

Medinas, Danilo ^{[5
,6
,7
]}

Bustamante, Gonzalo ^{[2
]}

Pasquali, Renzo ^{[1
]}

Hetz, Claudio ^{[5
,6
,7
]}

机构：

[1] Univ Chile, Fac Med, Dept Ciencias Neurol Oriente, Santiago, Chile

[2] Hosp Salvador, Serv Neurol, Santiago, Chile

[3] Inst Neurocirugia Dr Asenjo, Santiago, Chile

[4] Univ Santiago Chile, Escuela Postgrad, Santiago, Chile

[5] Univ Chile, Fac Med, Biomed Neurosci Inst, Santiago, Chile

[6] Univ Chile, Fac Med, Program Cellular & Mol Biol, Ctr Mol Studies Cell,ICBM, Santiago, Chile

[7] FONDAP Ctr Gerosci Brain Hlth & Metab, Santiago, Chile

来源：

REVISTA MEDICA DE CHILE | 2016年 / 144卷 / 06期

关键词：

Biomarkers; Creutzfeld-Jacob Syndrome; Electroencephalography; Status Epilepticus; NONCONVULSIVE STATUS EPILEPTICUS; 14-3-3; PROTEIN; DIAGNOSIS; EEG;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Creutzfeldt-Jakob disease has a higher incidence in Chile than in other countries. The post mortem pathological characterization of brain tissue is necessary to reach a definitive diagnosis. We report a 73 years old man with a history compatible with of a rapidly progressive dementia, in which the first electroencephalographic study showed a pattern consistent with non-convulsive status epilepticus. Besides discarding this diagnosis, it was necessary to rule out other causes of rapidly progressive dementia such as Hashimoto encephalopathy. Finally, the sustained clinical deterioration with no response to anticonvulsants and corticosteroids, the imaging studies, a serial electroencephalographic monitoring study and the detection of 14-3-3 protein in cerebrospinal fluid were the keys to achieve the diagnosis of the disease.

引用

页码：806 / 811

页数：6

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