Human muscle-derived cell injection in a rat model of stress urinary incontinence

被引：19
|
作者：
Kim, Yong Tae
Kim, Dae Kyung
Jankowski, Ron J.
Pruchnic, Ryan
Usiene, Irmute
de Miguel, Fernando
Chancellor, Michael B.
机构：
[1] Univ Pittsburgh, Dept Urol, Pittsburgh, PA 15123 USA
[2] Hanyang Univ, Dept Urol, Seoul 133791, South Korea
[3] Eulji Univ, Dept Urol, Taejon, South Korea
[4] Cook MyoSite, Pittsburgh, PA USA
来源：
MUSCLE & NERVE | 2007年 / 36卷 / 03期
关键词：
incontinence; muscle; skeletal muscle; stem cell; stress urinary incontinence; urethra;
D O I：
10.1002/mus.20827
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We investigated the use of human muscle-derived cells (hMDCs) for the treatment of stress urinary incontinence (SUI) in a nude rat model. hMDCs were isolated from adult skeletal muscle. Three groups of six animals consisting of controls, animals undergoing sciatic nerve transection (SNT) with periurethral sham-injection, and SNT with hMDCs (1 x 10(6) cells/20 mu l saline) were utilized. Leak point pressure (LPP) was measured 4 weeks following injection. Bilateral SNT resulted in a significantly lower LPP that was significantly higher following hMDCs than sham injection. The results demonstrate the efficacy of human muscle cell therapy alone in improving physiologic outcomes in an animal model of SUI.
引用
收藏
页码：391 / 393
页数：3
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