Forkhead Box Transcription Factors: Double-Edged Swords in Cancer

被引：52
作者：
Castaneda, Maria [1 ]
den Hollander, Petra [1 ]
Mani, Sendurai A. [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Translat Mol Pathol, 2130 West Holcombe Blvd,Suite 910, Houston, TX 77030 USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 11期
关键词：
EPITHELIAL-MESENCHYMAL TRANSITION; ESTROGEN-RECEPTOR-ALPHA; NF-KAPPA-B; PROSTATE-CANCER; ANDROGEN RECEPTOR; BREAST-CANCER; HEPATOCELLULAR-CARCINOMA; FOXC2; PROMOTES; FOXM1; MOLECULAR-MECHANISMS;
D O I：
10.1158/0008-5472.CAN-21-3371
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A plethora of treatment options exist for cancer therapeutics, their regulation of the epithelial–mesenchymal transition. Fork-but many are limited by side effects and either intrinsic or head factors can influence cancer development, progression, acquired resistance. The need for more effective targeted cancer metastasis, and drug resistance. In this review, we discuss the treatment has led to the focus on forkhead box (FOX) transcripvarious roles of forkhead factors in biological processes that tion factors as possible drug targets. Forkhead factors such as support cancer as well as their function as pioneering factors FOXA1 and FOXM1 are involved in hormone regulation, and their potential as targetable transcription factors in the fight immune system modulation, and disease progression through against cancer. ©2022 The Authors
引用
收藏
页码：2057 / 2065
页数：9
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